Genetic Toxicology - Bacterial Mutagenicity

Study Information
Study Attribute	Value
CEBS Accession Number:	002-02945-0005-0000-7
Chemical Name:	Trichloroethylene
CASRN:	79-01-6
NTP Study Type:	Genetic Toxicology - Bacterial Mutagenicity
NTP Study ID:	574937
Vehicle Control:	Dimethyl Sulfoxide
Study Result:	Negative

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Table Instructions and Notes:
You are currently viewing the results for this Salmonella study's detailed data.
Individual strain data is presented as mean ± standard error.
Abbreviations are noted at bottom of page.
Trial summary calls are shown in parentheses.
Standard NTP Protocol

Strain: TA100
Dose	No Activation (Positive)		No Activation (Negative)		10% RLI (Positive)		10% RLI (Negative)
Protocol	Plate Test - Vapor from liquid		Preincubation		Plate Test - Vapor from liquid		Preincubation
ug/Plate	Mean	±SEM	Mean	±SEM	Mean	±SEM	Mean	±SEM
0	84	1.9	106	2.3	90	2.3	117	10.4
0.32	93	1.8			114	9.6
0.63	98	3.5			154	2.3
2.5	162	.9			169	8.2
1.25	138	4.6			173	9.3
33			102	6.7			112	7.8
100			98	8.4			101	6.4
333			92	11			112	3.2
1000			92	1.2			100	6.9
3333			84	6.1			92 s	5.4
10000			72 s	2.1			101 s	11.4
Positive Control	692	32.5			1005	14.5	693	38.1

Strain: TA1535
Dose	No Activation (Positive)		No Activation (Negative)		10% RLI (Positive)		10% RLI (Negative)
Protocol	Plate Test - Vapor from liquid		Preincubation		Plate Test - Vapor from liquid		Preincubation
ug/Plate	Mean	±SEM	Mean	±SEM	Mean	±SEM	Mean	±SEM
0	7	1.5	8	2	8	1.5	11	.9
0.32	16	1.7			12	3.8
0.63	26	.9			19	2.6
2.5	98	8.5			79	4.7
1.25	51	4.2			53	1.7
33			11	1.2			10	.3
100			8	1.3			8	1.5
333			11	.9			12	2
1000			12	1.2			10	.3
3333			10	1.7			8	1.5
10000			11 s	1.5			9 s	2.4
Positive Control	37	2.4			51	3.8	105	2.4

Abbreviations:
RLI = induced male Sprague Dawley rat liver S9
HLI = induced male Syrian hamster liver S9
s = Slight Toxicity; p = Precipitate; x = Slight Toxicity and Precipitate; t = Toxic;