Genetic Toxicology - Bacterial Mutagenicity

Study Information
Study Attribute	Value
CEBS Accession Number:	002-03027-0001-0000-5
Chemical Name:	alpha-Methyl cinnamaldehyde
CASRN:	101-39-3
NTP Study Type:	Genetic Toxicology - Bacterial Mutagenicity
NTP Study ID:	543228
Vehicle Control:	Dimethyl Sulfoxide
Study Result:	Negative

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Table Instructions and Notes:
You are currently viewing the results for this Salmonella study's detailed data.
Individual strain data is presented as mean ± standard error.
Abbreviations are noted at bottom of page.
Trial summary calls are shown in parentheses.
Standard NTP Protocol

Strain: TA100
Dose	No Activation (Negative)		No Activation (Negative)		10% RLI (Negative)		10% RLI (Negative)		10% HLI (Negative)		10% HLI (Negative)
Protocol	Preincubation		Preincubation		Preincubation		Preincubation		Preincubation		Preincubation
ug/Plate	Mean	±SEM	Mean	±SEM	Mean	±SEM	Mean	±SEM	Mean	±SEM	Mean	±SEM
0	123	.7	194	4.2	109	4.2	165	2.5	130	5.3	160	7.2
3.3	131	4.7	181	6.2
10	129	5.2	164	8.5	133	8.2	181	5.2	162	5.7	158	12.7
33	98	4.6	185	11.2	140	5.2	175	3.8	147	4.4	170	4.4
100	124	3.5	179	3.3	111	12.4	192	9.2	125	4.2	155	4.7
300			140 s	12.7
333	96 s	4.3			131	1.2	173	7.8	132	5.5	159	10.7
500							136 s	1.5			118 s	2
666					94 s	15.6			87 s	8.5
Positive Control	1141	36.1	1341	15.3	580	22.2	1173	71.8	668	16.8	1258	152.2

Strain: TA1535
Dose	No Activation (Negative)		No Activation (Negative)		10% RLI (Negative)		10% RLI (Negative)		10% HLI (Negative)		10% HLI (Negative)
Protocol	Preincubation		Preincubation		Preincubation		Preincubation		Preincubation		Preincubation
ug/Plate	Mean	±SEM	Mean	±SEM	Mean	±SEM	Mean	±SEM	Mean	±SEM	Mean	±SEM
0	23	3.1	27	2.5	19	1.2	10	1	16	1.9	13	3
3.3	28	3.4	27	4.2
10	30	4.4	32	3.3	23	1.2	13	1.3	17	2.8	11	1.3
33	24	4.3	30	1.9	22	1.2	13	4.2	28	3.1	13	0
100	34	3.7	27	3.9	13	4	10	.9	16	3.8	9	2
300			t
333	t				20	1.5	11	3.8	23	3.8	8	1.5
500							7 s	2.3			6 s	1.2
666					7 s	.3			10 s	4.5
Positive Control	1003	81.2	1116	20.5	82	7.1	117	9.5	111	6.4	94	5.7

Strain: TA1537
Dose	No Activation (Negative)		No Activation (Negative)		10% RLI (Negative)		10% RLI (Negative)		10% HLI (Negative)		10% HLI (Negative)
Protocol	Preincubation		Preincubation		Preincubation		Preincubation		Preincubation		Preincubation
ug/Plate	Mean	±SEM	Mean	±SEM	Mean	±SEM	Mean	±SEM	Mean	±SEM	Mean	±SEM
0	6	1.5	13	3.7	7	2.3	11	1.8	4	.6	7	.9
3.3	7	1.3	10	2.4
10	5	1	11	1.7	7	.6	14	1.2	9	1.2	7	1.5
33	6	1.2	9	.9	7	.3	10	3.1	11	1.3	11	1.2
100	7	.7	8	1.5	7	1.8	6	.3	9	2.9	9	.7
300			4 s	.3
333	3 s	1.2			9	.9	11	2.9	7	.3	8	.9
500							5 s	2.7			4 s	1.2
666					5 s	.5			t
Positive Control	326	57.4	288	17.3	45	6.1	97	11.4	64	5.2	101	3.5

Strain: TA98
Dose	No Activation (Negative)		No Activation (Negative)		10% RLI (Negative)		10% RLI (Negative)		10% HLI (Negative)		10% HLI (Negative)
Protocol	Preincubation		Preincubation		Preincubation		Preincubation		Preincubation		Preincubation
ug/Plate	Mean	±SEM	Mean	±SEM	Mean	±SEM	Mean	±SEM	Mean	±SEM	Mean	±SEM
0	24	.3	22	3.3	29	2.9	33	3.5	29	2.4	30	3.3
3.3	17	.3	20	2.7
10	16	.3	25	3.1	28	3.5	30	2.6	27	2.3	26	.9
33	19	3.2	16	1.7	24	1.5	30	3.5	30	.6	36	1.5
100	15	1.5	25	1.7	21	1.5	25	1	38	.6	28	4.3
300			8 s	.6
333	11 s	1.9			25	1.8	22	6	31	2	23	1.3
500							19 s	3.6			16 s	1.2
666					t				t
Positive Control	1387	61.3	1698	30.4	394	19.2	789	42.8	535	28.3	923	100.3

Abbreviations:
RLI = induced male Sprague Dawley rat liver S9
HLI = induced male Syrian hamster liver S9
s = Slight Toxicity; p = Precipitate; x = Slight Toxicity and Precipitate; t = Toxic;