Genetic Toxicology - Bacterial Mutagenicity

Study Information
Study Attribute	Value
CEBS Accession Number:	002-03027-0002-0000-6
Chemical Name:	alpha-Methyl cinnamaldehyde
CASRN:	101-39-3
NTP Study Type:	Genetic Toxicology - Bacterial Mutagenicity
NTP Study ID:	981636
Vehicle Control:	Dimethyl Sulfoxide
Study Result:	Negative

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Table Instructions and Notes:
You are currently viewing the results for this Salmonella study's detailed data.
Individual strain data is presented as mean ± standard error.
Abbreviations are noted at bottom of page.
Trial summary calls are shown in parentheses.
Standard NTP Protocol

Strain: TA100
Dose	No Activation (Negative)		No Activation (Negative)		10% RLI (Equivocal)		10% RLI (Negative)		10% MLI (Equivocal)		10% MLI (Equivocal)		10% MLI (Negative)
Protocol	Preincubation		Preincubation		Preincubation		Preincubation		Preincubation		Preincubation		Preincubation
ug/Plate	Mean	±SEM	Mean	±SEM	Mean	±SEM	Mean	±SEM	Mean	±SEM	Mean	±SEM	Mean	±SEM
0	92	8.4	115	4.2	116	5.5	103	5.5	101	7.2	110	5.2	97	5.5
10	88	2.6					95	6	97	3.7
33	91	6.8					104	2.8	99	3.3
100	81	2.5	115	3.5	133	2.7	106	11.6	109	6.5	103	9.8	89	1.7
300			107	.6	125	4.3					110	5.7
333	69	3.8					95	5.5	138	5.8			98	3.5
500			97	4.4	149	8.6					121	2.7
700			110	7	160	4.2					149	10.7
900			111 s	5	128 s	9.3					172 s	8.7
1000	27 s	5.7					76 s	4.4	118 s	11			99	4.2
3333													104	4.3
10000													9 s	3.2
Positive Control	327	13.6	347	5.2	349	4.4	1226	24	1899	49.9	374	8.2	1310	99.3

Strain: TA102
Dose	No Activation (Negative)		No Activation (Negative)		10% RLI (Negative)		10% RLI (Negative)		10% RLI (Negative)		10% MLI (Negative)		10% MLI (Negative)
Protocol	Preincubation		Preincubation		Preincubation		Preincubation		Preincubation		Preincubation		Preincubation
ug/Plate	Mean	±SEM	Mean	±SEM	Mean	±SEM	Mean	±SEM	Mean	±SEM	Mean	±SEM	Mean	±SEM
0	242	21.3	244	11.3	292	15.5	242	23.1	344	25.5	285	18.6	343	21.5
10	256	1.2			294	33.9
33	252	11.8			288	8.9
100	230	9	220	9.5	249	23.5	292	21.2	363	25.8	271	13.5	315	26.6
300			190	6.2					335	34.8			329	12.8
333	226	3.2			250	8.5	312	12.4			301	15.2
500			150	6.7					360	12.1			314	7.9
700			158	12.2					326	18			281	1.8
900			185 s	9.2					259 s	24.6			246 s	22.8
1000	14 s	7.5			109 s	44.5	298	11			241	7.2
3333							255	15.5			281	16.5
10000							142 s	36.3			195 s	15.7
Positive Control	780	26.8	1564	51.6	383	40.7	408	22.1	612	27.5	448	19.1	677	22.7

Strain: TA104
Dose	No Activation (Negative)		No Activation (Negative)		10% RLI (Negative)		10% RLI (Negative)		10% MLI (Negative)		10% MLI (Negative)
Protocol	Preincubation		Preincubation		Preincubation		Preincubation		Preincubation		Preincubation
ug/Plate	Mean	±SEM	Mean	±SEM	Mean	±SEM	Mean	±SEM	Mean	±SEM	Mean	±SEM
0	351	28.6	377	4.5	412	29.7	464	18.8	379	16.4	391	15.2
10					382	14.5			384	33.7
33					370	10.7			380	18
100	342	20.5	343	10.4	351	4.3	447	12.5	370	21.6	351	7.6
300			352	2.7			419	18.8			355	6.3
333	358	22.2			321	7.9			370	10.5
500			234	11.5			368	12.4			348	5.6
700			197	10.1			337	13.5			350	25.2
900			282 s	34.5			360 s	10.7			261 s	17.1
1000	376	3.8			169 s	20.7			223 s	8.7
3333	355	7.6
10000	228 s	9.5
Positive Control	835	60.5	958	21.5	1105	20.8	715	12.9	1491	194.8	552	9.8

Abbreviations:
RLI = induced male Sprague Dawley rat liver S9
HLI = induced male Syrian hamster liver S9
s = Slight Toxicity; p = Precipitate; x = Slight Toxicity and Precipitate; t = Toxic;