Genetic Toxicology - Bacterial Mutagenicity

Study Information
Study Attribute	Value
CEBS Accession Number:	002-03105-0001-0000-2
Chemical Name:	o,o-Diethyl S-(((1,1-dimethylethyl)thio)methyl)phoshorodithioate
CASRN:	13071-79-9
NTP Study Type:	Genetic Toxicology - Bacterial Mutagenicity
NTP Study ID:	446046
Vehicle Control:	Dimethyl Sulfoxide
Study Result:	Negative

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Table Instructions and Notes:
You are currently viewing the results for this Salmonella study's detailed data.
Individual strain data is presented as mean ± standard error.
Abbreviations are noted at bottom of page.
Trial summary calls are shown in parentheses.
Standard NTP Protocol

Strain: TA100
Dose	No Activation (Negative)		No Activation (Negative)		10% RLI (Negative)		10% RLI (Negative)		10% HLI (Negative)		10% HLI (Negative)
Protocol	Preincubation		Preincubation		Preincubation		Preincubation		Preincubation		Preincubation
ug/Plate	Mean	±SEM	Mean	±SEM	Mean	±SEM	Mean	±SEM	Mean	±SEM	Mean	±SEM
0	114	6.7	107	11.3	121	4	109	7.8	122	9.5	98	7
100	120	5.7	113	13.1	118	2.9	108	3.4	146	12.6	105	1.7
333	126	4.4	100	9.7	126	5.5	112	1.2	140	11.1	101	5.8
1000	131	7.2	95	10.3	147	7.2	108	5	140	12.6	83	11.3
3333	119	7.2	98	6.8	146	5.5	103	3.8	151	7.2	94	3.2
10000	124	7.6	116	19.9	156	9.8	100	4.3	127	11.6	77	6.2
Positive Control	424	22	413	2.7	464	11.5	359	4.2	1412	49.8	1072	24.5

Strain: TA1535
Dose	No Activation (Negative)		No Activation (Negative)		10% RLI (Negative)		10% RLI (Negative)		10% HLI (Negative)		10% HLI (Negative)
Protocol	Preincubation		Preincubation		Preincubation		Preincubation		Preincubation		Preincubation
ug/Plate	Mean	±SEM	Mean	±SEM	Mean	±SEM	Mean	±SEM	Mean	±SEM	Mean	±SEM
0	25	.3	26	1	7	1.5	10	1.7	13	3	10	1.2
100	20	1.5	25	2.6	9	.7	11	4.2	21	.7	13	2.6
333	17	3.3	32	3.9	6	1.2	10	1.7	23	3.8	7	.3
1000	20	1.3	32	2.9	11	1.9	11	1.9	26	4.7	11	1.8
3333	23	3.7	37	5.5	11	1	7	2.5	22	.9	7	.9
10000	26	2.3	31	6.2	11	2.8	9	1.8	16	1.8	9	2.3
Positive Control	395	13.6	481	11.8	149	6.7	162	11	504	29.3	416	15.9

Strain: TA1537
Dose	No Activation (Negative)		No Activation (Negative)		10% RLI (Negative)		10% RLI (Negative)		10% HLI (Negative)		10% HLI (Negative)
Protocol	Preincubation		Preincubation		Preincubation		Preincubation		Preincubation		Preincubation
ug/Plate	Mean	±SEM	Mean	±SEM	Mean	±SEM	Mean	±SEM	Mean	±SEM	Mean	±SEM
0	5	1.2	4	1.5	9	2	6	.6	8	2.3	5	.3
100	7	.6	5	.7	7	1.5	9	1.7	18	1	6	.9
333	6	1.3	4	1.5	7	.9	6	.6	22	2.7	6	1.8
1000	9	1.2	4	.3	8	3.5	6	1.7	16	2.2	4	.7
3333	8	2.6	8	.9	7	1.5	11	2.3	20	1.9	6	1.2
10000	7	1.2	6	1.2	6	.9	10	1.7	18	3.2	10	3.3
Positive Control	106	12.5	154	8.4	174	8.1	111	6.8	357	24.3	433	16.1

Strain: TA98
Dose	No Activation (Negative)		No Activation (Negative)		10% RLI (Negative)		10% RLI (Negative)		10% HLI (Negative)		10% HLI (Negative)
Protocol	Preincubation		Preincubation		Preincubation		Preincubation		Preincubation		Preincubation
ug/Plate	Mean	±SEM	Mean	±SEM	Mean	±SEM	Mean	±SEM	Mean	±SEM	Mean	±SEM
0	14	3.8	16	.7	34	5.8	29	1	29	4.4	23	3.2
100	15	.6	19	1.2	32	1.5	34	2.7	42	6.1	28	1.5
333	15	1.2	21	2.3	32	2.5	24	5.2	48	2.7	28	4.3
1000	20	1.5	18	1.5	31	1.7	31	7.5	49	1.2	29	2.4
3333	16	1.5	20	3.2	25	0	26	3.2	44	3.5	26	0
10000	13	1.9	14	3.5	32	5.3	23	2.7	45	3.3	22	4.6
Positive Control	841	8.3	688	18.1	319	17.2	333	13.9	1474	19.1	1308	39

Abbreviations:
RLI = induced male Sprague Dawley rat liver S9
HLI = induced male Syrian hamster liver S9
s = Slight Toxicity; p = Precipitate; x = Slight Toxicity and Precipitate; t = Toxic;