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Study Information
Study Attribute Value
CEBS Accession Number: 002-03122-0001-0000-1
Chemical Name: o-Cresyl glycidyl ether
CASRN: 2210-79-9
NTP Study Type: Genetic Toxicology - Bacterial Mutagenicity
NTP Study ID: 141757
Vehicle Control: Dimethyl Sulfoxide
Study Result: Positive

Table Instructions and Notes:
You are currently viewing the results for this Salmonella study's detailed data.
Individual strain data is presented as mean ± standard error.
Abbreviations are noted at bottom of page.
Trial summary calls are shown in parentheses.
Standard NTP Protocol

Strain: TA100
Dose No Activation
(Positive)
No Activation
(Positive)
30% RLI
(Equivocal)
30% RLI
(Weakly Positive)
30% HLI
(Negative)
Protocol Preincubation Preincubation Preincubation Preincubation Preincubation
ug/Plate Mean ±SEM Mean ±SEM Mean ±SEM Mean ±SEM Mean ±SEM
 0         
136 8.4 99 3.8 156 5 108 4.1 137 8.7
3.3       
153 13.9 154 5.3
10         
170 6.9 168 10.3 151 5.2 122 3 140 4.9
33         
269 14.7 304 15.6 149 7.6 103 4.9 141 3.3
100         
538 s 29.3 618 19.4 157 9.4 123 2.3 135 2.6
333         
158 10.4 143 1.8
334         
1308 s 27.5 1355 s 15.9 166 9
667         
212 s 2.3 206 s 5.6 157 s 10.4
Positive Control 281 10.7 220 6.7 435 9.1 395 20.5 338 4.9

Strain: TA1535
Dose No Activation
(Positive)
No Activation
(Positive)
30% RLI
(Negative)
30% HLI
(Negative)
Protocol Preincubation Preincubation Preincubation Preincubation
ug/Plate Mean ±SEM Mean ±SEM Mean ±SEM Mean ±SEM
 0         
34 1.9 22 0 14 1.9 22 .9
3.3       
31 2.2 24 1.5
10         
49 4.8 34 5 22 2.3 18 1.5
33         
87 3.8 88 1.5 18 2.9 19 1.5
100         
249 6.6 190 6.9 23 4.6 15 3
333         
332 s 98.9 316 s 5.8 20 1.5 18 .6
666         
18 s 1.2 14 s 2.3
Positive Control 116 8.5 115 6.7 85 3.5 92 8.4

Strain: TA1537
Dose No Activation
(Negative)
30% RLI
(Negative)
30% HLI
(Negative)
Protocol Preincubation Preincubation Preincubation
ug/Plate Mean ±SEM Mean ±SEM Mean ±SEM
 0         
7 .6 9 1 6 1.2
3.3       
4 1.5
10         
6 1.7 11 1.3 9 1.8
33         
6 2.7 9 .5 10 1.2
100         
5 2.6 11 2.1 11 1.9
333         
10 s .9 9 .7 7 1
666         
11 s 1.5 5 s 1.5
Positive Control 344 17.6 35 1.5 75 6.4

Strain: TA98
Dose No Activation
(Negative)
30% RLI
(Negative)
30% HLI
(Negative)
Protocol Preincubation Preincubation Preincubation
ug/Plate Mean ±SEM Mean ±SEM Mean ±SEM
 0         
16 1.2 20 3.1 19 2.5
3.3       
16 1.2
10         
16 1.9 23 3.5 23 3.4
33         
15 1.7 21 2.6 27 2.8
100         
15 2 18 1 22 .9
333         
27 3.8 29 1.5
334         
17 s 4.3
667         
18 4 23 s 2
Positive Control 136 5.8 92 1.5 64 6.5

Abbreviations:
RLI = induced male Sprague Dawley rat liver S9
HLI = induced male Syrian hamster liver S9
s = Slight Toxicity; p = Precipitate; x = Slight Toxicity and Precipitate; t = Toxic;