Study Attribute | Value |
---|---|
CEBS Accession Number: | 002-02303-0003-0000-3 |
Chemical Name: | Isobutene |
CASRN: | 115-11-7 |
NTP Study Type: | Genetic Toxicology - Micronucleus |
NTP Study ID: | A91962 |
Strain and Species: | B6C3F1 Mouse |
Study Result: | Male: Negative; Female: Negative |
Blood
Start Date | Sample Collection Time | Sex | Cell | Methodology Used | Dosing Regimen | Route | Trend Test P-Value |
---|---|---|---|---|---|---|---|
1992-01-21 | 24 hour | Male | NCE | Slide Scoring | Inhalation x 67, 92 day | Inhalation | 0.086 |
Dose (ppm) | Number of Animals Scored | Mean MN-NCE/1000 NCE ± SEM | Pairwise P | ||||
---|---|---|---|---|---|---|---|
Vehicle Control | Air | 0 |
5 | 1.100 ± 0.370 | |||
Test Chemical | Isobutene | 500 |
5 | 1.400 ± 0.330 | 0.274 | ||
1000 |
5 | 1.700 ± 0.120 | 0.128 | ||||
2000 |
5 | 1.700 ± 0.200 | 0.128 | ||||
4000 |
5 | 1.600 ± 0.330 | 0.168 | ||||
8000 |
5 | 2.000 ± 0.470 | 0.053 |
Blood
Start Date | Sample Collection Time | Sex | Cell | Methodology Used | Dosing Regimen | Route | Trend Test P-Value |
---|---|---|---|---|---|---|---|
1992-01-22 | 24 hour | Female | NCE | Slide Scoring | Inhalation x 67, 92 day | Inhalation | 0.541 |
Dose (ppm) | Number of Animals Scored | Mean MN-NCE/1000 NCE ± SEM | Pairwise P | ||||
---|---|---|---|---|---|---|---|
Vehicle Control | Air | 0 |
5 | 0.800 ± 0.200 | |||
Test Chemical | Isobutene | 500 |
5 | 1.000 ± 0.320 | 0.319 | ||
1000 |
5 | 1.100 ± 0.290 | 0.246 | ||||
2000 |
5 | 0.600 ± 0.100 | 0.704 | ||||
4000 |
5 | 1.200 ± 0.250 | 0.185 | ||||
8000 |
5 | 0.800 ± 0.250 | 0.500 |