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Study Information
Study Attribute Value
CEBS Accession Number: 002-01006-0007-0000-6
Chemical Name: Wyeth 14,643 (WY)
CASRN: 50892-23-4
NTP Study Type: Genetic Toxicology - Micronucleus
NTP Study ID: A06279
Strain and Species: TGAC (FVB/N) HOMOZYGOUS Mouse
Study Result: Male: Negative; Female: Negative

Blood

Start Date Sample Collection Time Sex Cell Methodology Used Dosing Regimen Route Trend Test P-Value
1999-06-17 24 hour Female PCE Slide Scoring Dosed-Feed x 182, 26 week Dosed-Feed 0.082
  Dose (ppm) Number of Animals Scored Mean MN-PCE/1000 PCE ± SEM Pairwise P
Vehicle Control Feed 
 0         
 11 1.450 ± 0.280
Test Chemical Wyeth 14,643 (WY) 
10         
 0.000 ± 0.000 
50         
 0.000 ± 0.000 
100         
 12 2.250 ± 0.590 0.082

Start Date Sample Collection Time Sex Cell Methodology Used Dosing Regimen Route Trend Test P-Value
1999-06-17 24 hour Female PCE Slide Scoring Dosed-Feed x 182, 26 week Dosed-Feed
  Dose (ppm) Number of Animals Scored Mean Percent PCE ± SEM Pairwise P
Vehicle Control Feed 
 0         
 11 2.830 ± 0.120
Test Chemical Wyeth 14,643 (WY) 
10         
 0.000 ± 0.000 
50         
 0.000 ± 0.000 
100         
 12 2.680 ± 0.120

Start Date Sample Collection Time Sex Cell Methodology Used Dosing Regimen Route Trend Test P-Value
1999-06-17 24 hour Female NCE Slide Scoring Dosed-Feed x 182, 26 week Dosed-Feed 0.412
  Dose (ppm) Number of Animals Scored Mean MN-NCE/1000 NCE ± SEM Pairwise P
Vehicle Control Feed 
 0         
 11 2.180 ± 0.400
Test Chemical Wyeth 14,643 (WY) 
10         
 11 2.270 ± 0.240 0.443 
50         
 12 2.330 ± 0.410 0.405 
100         
 12 2.330 ± 0.430 0.405

Blood

Start Date Sample Collection Time Sex Cell Methodology Used Dosing Regimen Route Trend Test P-Value
1999-06-17 24 hour Male PCE Slide Scoring Dosed-Feed x 182, 26 week Dosed-Feed 0.116
  Dose (ppm) Number of Animals Scored Mean MN-PCE/1000 PCE ± SEM Pairwise P
Vehicle Control Feed 
 0         
 11 1.730 ± 0.300
Test Chemical Wyeth 14,643 (WY) 
10         
 0.000 ± 0.000 
50         
 0.000 ± 0.000 
100         
 14 2.430 ± 0.400 0.116

Start Date Sample Collection Time Sex Cell Methodology Used Dosing Regimen Route Trend Test P-Value
1999-06-17 24 hour Male PCE Slide Scoring Dosed-Feed x 182, 26 week Dosed-Feed
  Dose (ppm) Number of Animals Scored Mean Percent PCE ± SEM Pairwise P
Vehicle Control Feed 
 0         
 11 2.600 ± 0.100
Test Chemical Wyeth 14,643 (WY) 
10         
 0.000 ± 0.000 
50         
 0.000 ± 0.000 
100         
 14 3.050 ± 0.070

Start Date Sample Collection Time Sex Cell Methodology Used Dosing Regimen Route Trend Test P-Value
1999-06-17 24 hour Male NCE Slide Scoring Dosed-Feed x 182, 26 week Dosed-Feed 0.111
  Dose (ppm) Number of Animals Scored Mean MN-NCE/1000 NCE ± SEM Pairwise P
Vehicle Control Feed 
 0         
 11 2.180 ± 0.350
Test Chemical Wyeth 14,643 (WY) 
10         
 14 2.000 ± 0.300 0.623 
50         
 12 3.170 ± 0.490 0.075 
100         
 14 2.640 ± 0.440 0.232