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Study Information
Study Attribute Value
CEBS Accession Number: 002-01006-0008-0000-7
Chemical Name: Wyeth 14,643 (WY)
CASRN: 50892-23-4
NTP Study Type: Genetic Toxicology - Micronucleus
NTP Study ID: A71798
Strain and Species: TGAC (FVB/N) HOMOZYGOUS Mouse
Study Result: Male: Negative; Female: Negative

Blood

Start Date Sample Collection Time Sex Cell Methodology Used Dosing Regimen Route Trend Test P-Value
2001-08-02 24 hour Male PCE Slide Scoring Dermal x 130, 26 week Dermal 0.802
  Dose (mg/kg) Number of Animals Scored Mean MN-PCE/1000 PCE ± SEM Pairwise P
Vehicle Control Acetone 
 0         
 10 2.800 ± 0.490
Test Chemical Wyeth 14,643 (WY) 
2         
 0.000 ± 0.000 
10         
 0.000 ± 0.000 
20         
 10 2.200 ± 0.330 0.802

Start Date Sample Collection Time Sex Cell Methodology Used Dosing Regimen Route Trend Test P-Value
2001-08-02 24 hour Male PCE Slide Scoring Dermal x 130, 26 week Dermal
  Dose (mg/kg) Number of Animals Scored Mean Percent PCE ± SEM Pairwise P
Vehicle Control Acetone 
 0         
 10 3.650 ± 0.140
Test Chemical Wyeth 14,643 (WY) 
2         
 0.000 ± 0.000 
10         
 0.000 ± 0.000 
20         
 10 3.140 ± 0.170

Start Date Sample Collection Time Sex Cell Methodology Used Dosing Regimen Route Trend Test P-Value
2001-08-02 24 hour Male NCE Slide Scoring Dermal x 130, 26 week Dermal 0.034
  Dose (mg/kg) Number of Animals Scored Mean MN-NCE/1000 NCE ± SEM Pairwise P
Vehicle Control Acetone 
 0         
 10 3.200 ± 0.550
Test Chemical Wyeth 14,643 (WY) 
2         
 10 3.300 ± 0.450 0.451 
10         
 10 3.900 ± 0.380 0.203 
20         
 10 4.600 ± 0.620 0.056

Blood

Start Date Sample Collection Time Sex Cell Methodology Used Dosing Regimen Route Trend Test P-Value
2001-08-03 24 hour Female PCE Slide Scoring Dermal x 130, 26 week Dermal 0.944
  Dose (mg/kg) Number of Animals Scored Mean MN-PCE/1000 PCE ± SEM Pairwise P
Vehicle Control Acetone 
 0         
 10 4.000 ± 0.700
Test Chemical Wyeth 14,643 (WY) 
2         
 0.000 ± 0.000 
10         
 0.000 ± 0.000 
20         
 10 2.700 ± 0.560 0.944

Start Date Sample Collection Time Sex Cell Methodology Used Dosing Regimen Route Trend Test P-Value
2001-08-03 24 hour Female PCE Slide Scoring Dermal x 130, 26 week Dermal
  Dose (mg/kg) Number of Animals Scored Mean Percent PCE ± SEM Pairwise P
Vehicle Control Acetone 
 0         
 10 3.960 ± 0.190
Test Chemical Wyeth 14,643 (WY) 
2         
 0.000 ± 0.000 
10         
 0.000 ± 0.000 
20         
 10 7.550 ± 4.320

Start Date Sample Collection Time Sex Cell Methodology Used Dosing Regimen Route Trend Test P-Value
2001-08-03 24 hour Female NCE Slide Scoring Dermal x 130, 26 week Dermal 0.124
  Dose (mg/kg) Number of Animals Scored Mean MN-NCE/1000 NCE ± SEM Pairwise P
Vehicle Control Acetone 
 0         
 10 2.000 ± 0.370
Test Chemical Wyeth 14,643 (WY) 
2         
 10 3.100 ± 0.500 0.062 
10         
 10 2.900 ± 0.550 0.099 
20         
 10 3.200 ± 0.440 0.048