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Study Information
Study Attribute Value
CEBS Accession Number: 002-01370-0001-0000-4
Chemical Name: 2-Nitroethanol
CASRN: 625-48-9
NTP Study Type: Genetic Toxicology - Micronucleus
NTP Study ID: G625489
Strain and Species: B6C3F1 Mouse
Study Result: Male: Equivocal

Blood

Start Date Sample Collection Time Sex Cell Methodology Used Dosing Regimen Route Trend Test P-Value
2009-02-23 28 hour Male PCE Flow Cytometry Gavage x 4, 4 day Gavage 0.032
  Dose (mg/kg) Number of Animals Scored Mean MN-PCE/1000 PCE ± SEM Pairwise P
Vehicle Control Saline 
 0         
 5 3.140 ± 0.436
Test Chemical 2-Nitroethanol 
250         
 5 2.620 ± 0.274 1.000 
500         
 5 3.050 ± 0.227 1.000 
1000         
 5 5.877 ± 1.418 0.138
Positive Control Ethyl Methane Sulfonate 
150         
 5 10.245 ± 0.702 0.004

Start Date Sample Collection Time Sex Cell Methodology Used Dosing Regimen Route Trend Test P-Value
2009-02-23 28 hour Male PCE Flow Cytometry Gavage x 4, 4 day Gavage 0.000
  Dose (mg/kg) Number of Animals Scored Mean Percent PCE ± SEM Pairwise P
Vehicle Control Saline 
 0         
 5 1.254 ± 0.033
Test Chemical 2-Nitroethanol 
250         
 5 1.614 ± 0.070 1.000 
500         
 5 1.469 ± 0.050 1.000 
1000         
 5 0.384 ± 0.115 0.000
Positive Control Ethyl Methane Sulfonate 
150         
 5 1.147 ± 0.088 0.465

Start Date Sample Collection Time Sex Cell Methodology Used Dosing Regimen Route Trend Test P-Value
2009-02-23 28 hour Male NCE Flow Cytometry Gavage x 4, 4 day Gavage 0.216
  Dose (mg/kg) Number of Animals Scored Mean MN-NCE/1000 NCE ± SEM Pairwise P
Vehicle Control Saline 
 0         
 5 1.556 ± 0.046
Test Chemical 2-Nitroethanol 
250         
 5 1.467 ± 0.041 0.798 
500         
 5 1.535 ± 0.032 0.737 
1000         
 5 1.569 ± 0.024 0.504
Positive Control Ethyl Methane Sulfonate 
150         
 5 1.864 ± 0.056 0.001