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Study Information
Study Attribute Value
CEBS Accession Number: 002-02062-0003-0000-5
Chemical Name: Dimethyl hydrogen phosphite
CASRN: 868-85-9
NTP Study Type: Genetic Toxicology - Micronucleus
NTP Study ID: 224367
Strain and Species: B6C3F1 Mouse
Study Result: Male: Positive

Bone Marrow

Start Date Sample Collection Time Sex Cell Methodology Used Dosing Regimen Route Trend Test P-Value
1989-07-25 24 hour Male PCE Slide Scoring Intraperitoneal Injection x 3, 72 hour Intraperitoneal Injection 0.000
  Dose (mg/kg) Number of Animals Scored Mean MN-PCE/1000 PCE ± SEM Pairwise P
Vehicle Control Phosphate Buffered Saline 
 0         
 5 2.100 ± 0.640
Test Chemical Dimethyl hydrogen phosphite 
250         
 5 1.100 ± 0.370 0.962 
500         
 5 6.100 ± 0.940 Value less than 0.0001
Positive Control Mitomycin-C 
 0.2       
 5 5.800 ± 0.780 Value less than 0.0001

Start Date Sample Collection Time Sex Cell Methodology Used Dosing Regimen Route Trend Test P-Value
1989-07-25 24 hour Male PCE Slide Scoring Intraperitoneal Injection x 3, 72 hour Intraperitoneal Injection
  Dose (mg/kg) Number of Animals Scored Mean Percent PCE ± SEM Pairwise P
Vehicle Control Phosphate Buffered Saline 
 0         
 5 29.500 ± 3.750
Test Chemical Dimethyl hydrogen phosphite 
250         
 5 42.800 ± 1.880 
500         
 5 30.600 ± 2.770
Positive Control Mitomycin-C 
 0.2       
 5 37.800 ± 2.630

Bone Marrow

Start Date Sample Collection Time Sex Cell Methodology Used Dosing Regimen Route Trend Test P-Value
1989-11-28 24 hour Male PCE Slide Scoring Intraperitoneal Injection x 3, 72 hour Intraperitoneal Injection 0.078
  Dose (mg/kg) Number of Animals Scored Mean MN-PCE/1000 PCE ± SEM Pairwise P
Vehicle Control Phosphate Buffered Saline 
 0         
 5 2.700 ± 0.560
Test Chemical Dimethyl hydrogen phosphite 
250         
 5 2.200 ± 0.250 0.763 
500         
 3 4.170 ± 0.440 0.057
Positive Control Mitomycin-C 
 0.2       
 5 4.600 ± 0.370 0.013

Start Date Sample Collection Time Sex Cell Methodology Used Dosing Regimen Route Trend Test P-Value
1989-11-28 24 hour Male PCE Slide Scoring Intraperitoneal Injection x 3, 72 hour Intraperitoneal Injection
  Dose (mg/kg) Number of Animals Scored Mean Percent PCE ± SEM Pairwise P
Vehicle Control Phosphate Buffered Saline 
 0         
 5 50.300 ± 5.050
Test Chemical Dimethyl hydrogen phosphite 
250         
 5 41.700 ± 4.310 
500         
 3 19.670 ± 2.240
Positive Control Mitomycin-C 
 0.2       
 5 58.900 ± 3.330