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Study Information
Study Attribute Value
CEBS Accession Number: 002-02945-0003-0000-5
Chemical Name: Trichloroethylene
CASRN: 79-01-6
NTP Study Type: Genetic Toxicology - Micronucleus
NTP Study ID: 679194
Strain and Species: B6C3F1 Mouse
Study Result: Male: Negative

Bone Marrow

Start Date Sample Collection Time Sex Cell Methodology Used Dosing Regimen Route Trend Test P-Value
1989-07-25 24 hour Male PCE Slide Scoring Intraperitoneal Injection x 3, 72 hour Intraperitoneal Injection 0.835
  Dose (mg/kg) Number of Animals Scored Mean MN-PCE/1000 PCE ± SEM Pairwise P
Vehicle Control Corn Oil 
 0         
 5 2.300 ± 0.490
Test Chemical Trichloroethylene 
500         
 5 2.800 ± 0.540 0.242 
1000         
 5 2.100 ± 0.330 0.619 
2000         
 6 1.920 ± 0.470 0.732
Positive Control Dimethylbenzanthracene 
12.5       
 5 8.600 ± 1.430 Value less than 0.0001

Start Date Sample Collection Time Sex Cell Methodology Used Dosing Regimen Route Trend Test P-Value
1989-07-25 24 hour Male PCE Slide Scoring Intraperitoneal Injection x 3, 72 hour Intraperitoneal Injection
  Dose (mg/kg) Number of Animals Scored Mean Percent PCE ± SEM Pairwise P
Vehicle Control Corn Oil 
 0         
 5 63.400 ± 2.950
Test Chemical Trichloroethylene 
500         
 5 59.100 ± 4.450 
1000         
 5 65.800 ± 1.630 
2000         
 6 64.670 ± 5.240
Positive Control Dimethylbenzanthracene 
12.5       
 5 56.200 ± 2.840

Bone Marrow

Start Date Sample Collection Time Sex Cell Methodology Used Dosing Regimen Route Trend Test P-Value
1990-03-05 24 hour Male PCE Slide Scoring Intraperitoneal Injection x 3, 72 hour Intraperitoneal Injection 0.028
  Dose (mg/kg) Number of Animals Scored Mean MN-PCE/1000 PCE ± SEM Pairwise P
Vehicle Control Corn Oil 
 0         
 5 1.400 ± 0.240
Test Chemical Trichloroethylene 
2000         
 4 2.250 ± 0.430 0.089 
2500         
 5 2.600 ± 0.760 0.029 
3000         
 0.000 ± 0.000
Positive Control Dimethylbenzanthracene 
12.5       
 5 4.400 ± 0.760 Value less than 0.0001

Start Date Sample Collection Time Sex Cell Methodology Used Dosing Regimen Route Trend Test P-Value
1990-03-05 24 hour Male PCE Slide Scoring Intraperitoneal Injection x 3, 72 hour Intraperitoneal Injection
  Dose (mg/kg) Number of Animals Scored Mean Percent PCE ± SEM Pairwise P
Vehicle Control Corn Oil 
 0         
 5 59.300 ± 2.090
Test Chemical Trichloroethylene 
2000         
 4 64.500 ± 2.210 
2500         
 5 63.800 ± 1.470 
3000         
 0.000 ± 0.000
Positive Control Dimethylbenzanthracene 
12.5       
 5 56.800 ± 2.790

Blood

Start Date Sample Collection Time Sex Cell Methodology Used Dosing Regimen Route Trend Test P-Value
1989-07-25 24 hour Male PCE Slide Scoring Intraperitoneal Injection x 3, 72 hour Intraperitoneal Injection 0.678
  Dose (mg/kg) Number of Animals Scored Mean MN-PCE/1000 PCE ± SEM Pairwise P
Vehicle Control Corn Oil 
 0         
 5 3.300 ± 0.600
Test Chemical Trichloroethylene 
500         
 5 3.400 ± 0.620 0.451 
1000         
 5 3.200 ± 0.250 0.549 
2000         
 5 3.000 ± 0.350 0.648
Positive Control Dimethylbenzanthracene 
12.5       
 5 9.000 ± 1.640 Value less than 0.0001

Start Date Sample Collection Time Sex Cell Methodology Used Dosing Regimen Route Trend Test P-Value
1989-07-25 24 hour Male PCE Slide Scoring Intraperitoneal Injection x 3, 72 hour Intraperitoneal Injection
  Dose (mg/kg) Number of Animals Scored Mean Percent PCE ± SEM Pairwise P
Vehicle Control Corn Oil 
 0         
 5 3.440 ± 0.150
Test Chemical Trichloroethylene 
500         
 5 3.360 ± 0.230 
1000         
 5 3.760 ± 0.370 
2000         
 5 3.180 ± 0.310
Positive Control Dimethylbenzanthracene 
12.5       
 5 1.980 ± 0.210

Blood

Start Date Sample Collection Time Sex Cell Methodology Used Dosing Regimen Route Trend Test P-Value
1990-03-05 24 hour Male PCE Slide Scoring Intraperitoneal Injection x 3, 72 hour Intraperitoneal Injection 0.243
  Dose (mg/kg) Number of Animals Scored Mean MN-PCE/1000 PCE ± SEM Pairwise P
Vehicle Control Corn Oil 
 0         
 5 2.400 ± 0.100
Test Chemical Trichloroethylene 
2000         
 4 2.250 ± 0.320 0.582 
2500         
 5 3.100 ± 0.510 0.172 
3000         
 0.000 ± 0.000
Positive Control Dimethylbenzanthracene 
12.5       
 5 10.200 ± 1.850 Value less than 0.0001

Start Date Sample Collection Time Sex Cell Methodology Used Dosing Regimen Route Trend Test P-Value
1990-03-05 24 hour Male PCE Slide Scoring Intraperitoneal Injection x 3, 72 hour Intraperitoneal Injection
  Dose (mg/kg) Number of Animals Scored Mean Percent PCE ± SEM Pairwise P
Vehicle Control Corn Oil 
 0         
 5 3.760 ± 0.380
Test Chemical Trichloroethylene 
2000         
 4 4.300 ± 1.140 
2500         
 5 2.440 ± 0.130 
3000         
 0.000 ± 0.000
Positive Control Dimethylbenzanthracene 
12.5       
 5 2.320 ± 0.220