Parent Title:
Center for Childhood Asthma in the Urban Environment
Grant Number:
Principal Investigator:
Diette, Gregory B
Institution:
Johns Hopkins University
Most Recent Award Year:
2007
Lifestage of Participants:
Exposure:
Youth (1-18 years)
Assessment:
Youth (1-18 years)
Exposures:
Air Pollutants:
Particulate matter
Allergens:
Mouse allergens
Health Outcomes:
Respiratory Outcomes:
Asthma
Biological Sample:
Blood; Nasal lavage; Urine
Environmental Sample:
Air sample
Other Participant Data:
Lung function; Exhaled nitric oxide
Abstract:
Asthma is a common disorder among children. Children with asthma have multiple and complex environmental exposures, including inhalable pollutants and allergens. The response to inhaled exposures is characterized by airway inflammation, and possibly by activation of oxidative stress pathways. In the U.S., the burden of asthma is enormous, with a disproportionate impact on vulnerable groups including young children, African-Americans and those living in the inner city. These most vulnerable people often inhabit an environment that has excessive outdoor pollution levels, as well as high levels of indoor allergens and pollutants. We plan to address the critical questions of the role of the indoor environment on childhood asthma, we propose a panel study of children living in urban neighborhoods enriched with African-American and lower income participants. This real world field-based study will complement the findings from Projects 2, 3 and 4, which will similarly examine the effects of PM and allergen, but in controlled settings using human subjects, animal models and cell systems. We will recruit atopic asthmatics, including those with and without sensitization to mouse allergen, as well as normal controls, to address the following Specific Aims: Aim 1 .A: To determine the contribution of indoor PM to day-to-day variation in lung function and asthma control, among inner city children with atopic asthma. Aim IB: To determine if higher indoor PM exposure is associated with biomarkers of inflammation and oxidative stress. Aim 2A: To determine if mouse IgE-positive asthmatics with high mouse allergen exposure have greater susceptibility to PM than other atopic asthmatics (mouse IgE-negative and/or with low mouse allergen exposure). Aim 2.B: To determine if mouse IgE-positive asthmatics with high mouse allergen exposure (> 0.5 ug/g of Mus m 1) have elevated biomarkers of inflammation and oxidative stress in response to PM compared to those who are mouse IgE-E negative or who have low mouse allergen exposure.
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Related NIEHS-Funded Study Populations
Asthma Dietary Interventions to Protect Against Environmental Triggers (Asthma-DIET)
Principal Investigator:
Diette, Gregory
| Study Population Page Study Population c7
Institution:
Johns Hopkins University
Location:
Baltimore, Maryland
Number of Participants::
~200
Brief Description::
This is a longitudinal study examining how diet may affect susceptibility to asthmatic triggers from in-home pollutants among 200 inner city Baltimore children. Previous NIEHS-funded studies from the same catchment area have addressed similar outcomes.