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Your Environment. Your Health.

Metal Mixtures, Children's Cognition, and Sensitive Developmental Windows

Grant Number:
Principal Investigator:
Henn, Claus; Gunhild, Birgit
Harvard University
Most Recent Award Year:
Lifestage of Participants:
Exposure: Prenatal; Infant (0-1 year); Youth (1-18 years)
Assessment: Youth (1-18 years)
Metals: Chromium; Copper; Lead; Manganese
Health Outcomes:
Neurological/Cognitive Outcomes: Neurodevelopmental outcomes
Biological Sample:
Blood; Fingernails/toenails; Hair; Deciduous teeth; Urine

Related NIEHS-Funded Study Populations

Public Health Impact of Mixed Element Exposure in Susceptible Populations (PHIME)

Principal Investigator:
Icahn School of Medicine at Mount Sinai
Bagnolo Mella, Valcamonica, and Garda Lake, in the province of Brescia, Italy
Number of Participants::
Brief Description::
This is a longitudinal cohort study to investigate the neurological effects of long-term exposure to metals, especially manganese (Mn), on children living in three communities in Northern Italy that differ in the timing and intensity of environmental Mn exposure from current or historic ferromanganese alloy plant operations. Neurodevelopment and behavior were assessed in children at 11-13 years of age and again at 17-20 years of age.

Early Life Exposures in Mexico to Environmental Toxicants (ELEMENT)

Principal Investigator:
Hu, Howard; Peterson, Karen; Hernandez-Avila, Mauricio; Tellez-Rojo, Martha Maria | Study Population Page Study Population c49
University of Michigan
Mexico City, Mexico
Number of Participants::
Brief Description::
This is a group of three sequentially-enrolled, on-going, epidemiologic birth cohort studies in Mexico City with an original aim to investigate the impact of lead on child development. The research aims have since expanded to include a wide range health outcomes and environmental, nutritional, behavioral, genetic, and epigenetic risk factors. More than 1,600 mother-child pairs enrolled in the study beginning in 1994, some of whom have been followed for over two decades.
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