Skip Navigation

Project 1: Tobacco Smoke Exposure, Epigenetics and Cognitive Deficits in Children

Parent Title:
Neurodevelopment and Improving Children’s Health Following ETS Exposure (NICHES)
Grant Number:
Principal Investigator:
Fuemmeler, Bernard F; Kollins, Scott H
Duke University
Most Recent Award Year:
Lifestage of Participants:
Exposure: Prenatal (specifically first trimester); Infant (0-1, specficially at birth and first postnatal assessment); Youth (1-18 years, specifically 3-7 years of age); Adulthood (mother)
Assessment: Youth (1-18 years, specifically 3-7 years of age)
Air Pollutants: Tobacco smoke
Health Outcomes:
Neurological/Cognitive Outcomes: Attention deficit hyperactivity disorder (ADHD); Neurobehavioral outcomes; Cognitive and neurobehavioral function
Biological Sample:
Blood (mother, child); Cord blood; Saliva/buccal cells
Other Participant Data:
Smoking history surveys; Data from medical records; Executive functioning; Attention Deficit Disorder (ADHD)
Genes or Other DNA Products Studied:
Loci associated with neurobehavioral outcomes or loci known to be methylated in response to environmental tobacco smoke exposure (e.g., BDNF, NGF, IGF2/H19, DLK1/MEG3)
Epigenetic Mechanisms Studied:
DNA Methylation

Related NIEHS-Funded Study Populations

Newborn Epigenetics Study Cohort (NEST)

Principal Investigator:
Hoyo, Cathrine; Murphy, Susan | Study Population Page Study Population c178
Duke University
Durham, North Carolina
Number of Participants::
2,500 Mother-Infant Pairs
Brief Description::
This is a birth cohort study investigating how early life environmental exposures and nutrition affect DNA methylation profiles in newborns. Infants were followed throughout early childhood to determine if methylation profiles established in utero are associated with childhood obesity and neurobehavioral outcomes. Since 2004, NEST has enrolled more than 2,500 women in central North Carolina.
to Top