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Your Environment. Your Health.

Project 3: Placental Biomarkers of Exposure and Outcome

Parent Title:
Children's Environmental Health & Disease Prevention Research Center at Dartmouth
Grant Number:
Principal Investigator:
Marsit, Carmen Joseph (contact); Robbins, David J (subcontract, University of Miami)
Dartmouth College
Most Recent Award Year:
Lifestage of Participants:
Exposure: Prenatal; Adulthood (mother)
Assessment: Infant (0-1 year); Youth (1-18 years)
Metals: Arsenic
Health Outcomes:
Immune Outcomes: Immune function; Infection
Neurological/Cognitive Outcomes: Neurodevelopmental outcomes
Biological Sample:
Genes or Other DNA Products Studied:
Gene expression in Hedgehog (Hh) signaling pathway; Developmental genes; Metal inducing or metabolizing genes
Epigenetic Mechanisms Studied:
DNA methylation

Related NIEHS-Funded Study Populations

The New Hampshire Birth Cohort Study

Principal Investigator:
Dartmouth College
New Hampshire; Vermont
Number of Participants::
2,000+ Mother-infant pairs
Brief Description::
This is a prospective pregnancy cohort study of mothers who use private wells for household water in New Hampshire designed to evaluate maternal/child health impacts of arsenic and other contaminants. The study has recruited over 2,500 mother-infant pairs (over 4,000 individuals) since 2009.
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