Parent Title:
Lifecourse Exposures & Diet: Epigenetics, Maturation & Metabolic Syndrome
Grant Number:
Principal Investigator:
Meeker, John D (Contact); Padmanabhan, Vasantha
Institution:
University of Michigan
Most Recent Award Year:
2013
Lifestage of Participants:
Exposure:
Prenatal; Youth (1-18 years); Adulthood (mother)
Assessment:
Prenatal; Infant (0-1 year); Youth (1-18 years)
Exposures:
Metals:
Cadmium; Lead
Mixtures:
Personal Care/Consumer Products:
Bisphenol A (BPA); Phthalates
Health Outcomes:
Metabolic Outcomes:
Obesity/body weight
Physical growth:
Reproductive Outcomes:
Premature/delayed puberty
Biological Sample:
Blood (mother, child); Urine (mother, child)
Other Participant Data:
Testicular volume; Tanner stage; Height; Weight
Abstract:
There is great concern regarding the potential developmental and reproductive effects resulting from environmental exposure to endocrine disrupting compounds (EDCs). Recent population trends showing shifts in the age of puberty onset and progression have contributed to this concern, as has evidence for interrelationships between EDC exposures, overweight and obesity, and easier onset of puberty. Early and late puberty onset are associated with social and psychological challenges and may indicate risk of current or future endocrine-related disorders. EDCs, such as phthalates and BPA, have been hypothesized to be associated with earlier puberty, while animal and human studies suggest exposure to lead and cadmium may be associated with delayed growth and puberty onset via endocrine-mediated pathways. There are a lack of longitudinal studies that have considered exposure to these agents, individually and as mixtures, and at multiple sensitive stages of development, in relation to physical growth and sexual maturation. The proposed study will address these gaps by expanding on pilot work of the University of Michigan (UM) Formative P20 Children's Center to undertake a more robust (N = 400) prospective assessment of the relationship between exposure to a select mixture of EDCs (phthalates, BPA, lead, and cadmium) and the tempo of physical growth and timing of sexual maturation in a long-standing longitudinal cohort study in Mexico. Existing data on life stage lead exposure and anthropometry (height, weight, BMI) 6-month intervals between birth and 5 years of age will be utilized, along with newly collected data. In the proposed study, children in the ongoing cohort will be re-recruited for two clinic visits (18 months apart) between the ages of 8 and 15 where Tanner stages (along with testicular volume among boys), anthropometry, and skin fold thickness will be assessed by a clinician, a blood sample will be collected for analysis of lead and reproductive and thyroid hormones, and a urine sample will be collected for analysis of phthalates, BPA and cadmium. These same exposure measures will additionally be analyzed from samples collected at all 3 trimesters of pregnancy when the children were in utero. Four years of repeated self-reported Tanner stage
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Related NIEHS-Funded Study Populations
Early Life Exposures in Mexico to Environmental Toxicants (ELEMENT)
Principal Investigator:
Hu, Howard; Peterson, Karen; Hernandez-Avila, Mauricio; Tellez-Rojo, Martha Maria
| Study Population Page Study Population c49
Institution:
University of Michigan
Location:
Mexico City, Mexico
Number of Participants::
1,653
Brief Description::
This is a group of three sequentially-enrolled, on-going, epidemiologic birth cohort studies in Mexico City with an original aim to investigate the impact of lead on child development. The research aims have since expanded to include a wide range health outcomes and environmental, nutritional, behavioral, genetic, and epigenetic risk factors. More than 1,600 mother-child pairs enrolled in the study beginning in 1994, some of whom have been followed for over two decades.