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Project 3: Discovery of Xenobiotics Associated with Preterm Birth

Parent Title:
Puerto Rico Testsite for Exploring Contamination Threats (PROTECT)
Grant Number:
Principal Investigator:
Giese, Roger Wallace
Northeastern University
Most Recent Award Year:
Lifestage of Participants:
Exposure: Prenatal; Adulthood (mother)
Assessment: Infant (0-1 year, specifically at birth)
Other: Untargeted xenobiotics
Health Outcomes:
Birth Outcomes: Preterm birth
Biological Sample:
Placenta; Placental cell cultures; Urine (mother)
Environmental Sample:
Drinking water sample (tap water); Groundwater
Genes or Other DNA Products Studied:
DNA adducts

Related NIEHS-Funded Study Populations

Puerto Rico Testsite for Exploring Contamination Threats (PROTECT) Cohort

Principal Investigator:
Alshawabkeh, Akram; Cordero, Jose F; Meeker, John | Study Population Page Study Population c239
Northeastern University, University of Puerto Rico Medical Sciences Campus, University of Puerto Rico at Mayaguez, University of Georgia, University of Michigan
Northern Puerto Rico
Number of Participants::
~1,600 pregnant women with a target of 1,200 mother-child pair
Brief Description::
This is a prospective birth cohort study exploring environmental, clinical, demographic, behavioral, and other factors that contribute to risk of preterm birth in Puerto Rico. Around 1,600 pregnant women were enrolled in the study with the goal of 1,200 mother-child pairs. A separate follow on study, The Center for Research on Early Childhood Exposure and Development in Puerto Rico (CRECE), will assess additional exposures and health outcomes for a subset of the children through age four.
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