Grant Number:
Principal Investigator:
Sathyanarayana, Sheela
Institution:
Seattle Children's Hospital
Most Recent Award Year:
2014
Lifestage of Participants:
Exposure:
Prenatal; Adulthood (mother)
Assessment:
Infant (0-1 year)
Exposures:
Personal Care/Consumer Products:
Diethylhexyl phthalate (DEHP); Dibutyl phthalate (DBP); Di-isononyl phthalate (DINP); Benzyl butyl phthalate (BBzP)
Health Outcomes:
Birth Outcomes:
Reproductive tract malformations (anogenital distance)
Biological Sample:
Blood; Urine (mother)
Other Participant Data:
Reproductive hormone concentrations during pregnancy (total testosterone, free testosterone, estradiol, estriol, and free estriol)
Abstract:
The aim of this application is to test the role of prenatal sex steroid hormones as the link between first trimester phthalate (synthetic endocrine disrupting chemical) exposure and newborn anogenital distance (AGD). Primary genitourinary development and programming occurs in the first 5-18 weeks of human gestation when the developing fetus is extremely sensitive to changes in sex steroid hormone concentrations that direct genital differentiation and development. AGD develops during this programming window and is a hormone sensitive reproductive toxicity endpoint commonly used in animal studies. Changes in AGD are associated with clinically significant newborn reproductive tract abnormalities and reduced fertility and abnormal semen parameters later in life. The general population is widely exposed to phthalates which can affect hormone concentrations and function during gestation leading to adverse hormone-mediated outcomes in animal and humans, including changes in AGD. The Prenatal Environmental Exposure and Reproductive Hormone Concentrations (PERCH) study will use data and samples from The Infant Development and the Environment Study to determine the relationship between phthalate exposures and sex steroid hormone concentrations in early pregnancy. It will also examine the relationship between early pregnancy sex steroid hormones and AGD in male and female infants. PERCH will be the first study to examine phthalate exposures during the fetal genitourinary programming window in relation to sex steroid hormone concentrations and newborn AGD. Results have important implications for understanding the biological pathway in which phthalates may impact reproductive development as well as for policy surrounding phthalate exposures in vulnerable populations.
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Related NIEHS-Funded Study Populations
The Infant Development and Environment Study (TIDES)
Principal Investigator:
Swan, Shanna
| Study Population Page Study Population c109
Institution:
Icahn School of Medicine at Mount Sinai
Location:
San Francisco, California; Minneapolis, Minnesota; Rochester, New York; Seattle, Washington
Number of Participants::
1,000 Mothers and 758 Children
Brief Description::
This is a multi-site pregnancy study examining how the mother’s exposure to everyday chemicals while pregnant may affect the developing fetus. The study recruited approximately 1,000 pregnant women in 2010-2012 and examined 758 children at birth.