Grant Number:
Principal Investigator:
Ryan, Patrick H
Institution:
Cincinnati Children's Hospital Medical Center
Most Recent Award Year:
2015
Lifestage of Participants:
Exposure:
Youth (1-18 years)
Assessment:
Youth (1-18 years)
Exposures:
Air Pollutants:
Particulate matter (PM0.1/ultrafine particles)
Health Outcomes:
Respiratory Outcomes:
Lung function
Environmental Sample:
Air sample
Other Participant Data:
Lung function tests
Abstract:
Accurately measuring personal exposure to air pollutants remains the greatest obstacle to determining their impact on human health. The need for more precise exposure assessment is particularly evident for children and adolescents whose exposure can vary widely based on their time-activity patterns including time spent outdoors, at home, school, and in vehicles. In order to meet the need of epidemiologists to characterize personal exposure, we have developed and validated in laboratory settings a novel personal sensor capable of measuring, with high spatiotemporal resolution, exposure to ultrafine particles (UFP). Results of an initial field test found the sensor to be mobile, rugged, and able to provide accurate spatiotemporal measurements of personal UFP exposure. Feedback from children participating in the initial field test indicated that barriers to its use included its volume, weight, and noise. Therefore, we now propose a two-phase project to: 1) evaluate the usability of the sensor after reducing its size, weight, and noise while maintaining its previous measurement capabilities (R21 Phase) and 2) deploy the modified sensor to characterize personal UFP exposure for adolescents enrolled in the Cincinnati Childhood Allergy and Air Pollution Study (CCAAPS) and assess the impact of short-term and peak UFP exposure on respiratory health (R33 Phase). The proposed study represents a continued collaboration between tool-developers and environmental epidemiologists and will allow for the iterative refinement of a personal sensor for UFP exposure. In addition, the application of the sensor in a large-scale epidemiologic study during the R33 phase will address a significant research question regarding the association between short-term and peak UFP exposure and respiratory health. Successful completion of the proposed project will result in a new tool for measuring personal UFP exposure in real world settings and demonstrate the value of the sensor to address novel hypotheses through improved exposure assessment.
ExpandCollapse Abstract
Related NIEHS-Funded Study Populations
Cincinnati Childhood Allergy and Air Pollution Study (CCAAPS)
Principal Investigator:
Ryan, Patrick (LeMasters, Grace)
| Study Population Page Study Population c22
Institution:
Cincinnati Children’s Hospital Medical Center, University of Cincinnati
Location:
Ohio
Number of Participants::
762 Adult-infant pairs
Brief Description::
CCAAPS is a longitudinal cohort study of children born in the greater Cincinnati, Ohio region. CCAAPS objectives are to determine the association between traffic related air pollution, specifically diesel exhaust particles and: 1) the development of allergic disease and asthma, and 2) neurodevelopment in childhood. The study has recruited 762 participants from the Greater Cincinnati/Northern Kentucky area since 2001.