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Your Environment. Your Health.

Genetic Biomarkers of Polybrominated Biphenyl (PBB) Exposure

Grant Number:
Principal Investigator:
Smith, Alicia K (contact); Conneely, Karen
Emory University
Most Recent Award Year:
Lifestage of Participants:
Exposure: Prenatal; Infant (0-1 year); Youth (1-18 years); Adulthood (18+ years)
Assessment: Adulthood (18+ years)
Brominated Compounds: Polybrominated biphenyls (PBBs)
Health Outcomes:
Metabolic Outcomes: Thyroid dysfunction
Reproductive Outcomes: Premature/delayed puberty
Biological Sample:
Other Participant Data:
Thyroid hormone levels (T3, T4, and TSH)
Genes or Other DNA Products Studied:
Candidate genes in polybrominated biphenyl (PBB) metabolism pathways; GWAS to identify variants associated with PBB elimination rate; Genetic polymorphisms associated with DNA methylation patterns
Epigenetic Mechanisms Studied:
Genome-wide DNA methylation of CpG sites in leukocytes

Related NIEHS-Funded Study Populations

Michigan PBB Cohort

Principal Investigator:
Emory University
Number of Participants::
Brief Description::
This is a multi-generational cohort study to assess the effects of polybrominated biphenyl (PBB) exposure on a number of outcomes in men and women and their offspring after a widespread exposure incident in 1973. The Michigan PBB Registry was established in 1976 and enrolled approximately 4,000 farmers, chemical workers, and others with PBB exposure risk; children and grandchildren of original registrants have also been enrolled.
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