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Early Life Perfluoroalkyl Substance Exposure & Obesity: Mechanisms & Phenotyping

Grant Number:
Principal Investigator:
Braun, Joseph M
Institution:
Brown University
Most Recent Award Year:
2016
Lifestage of Participants:
Exposure: Prenatal; Infant (0-1 year); Youth (1-18 years); Adulthood (mother)
Assessment: Infant (0-1 year); Youth (1-18 years)
Exposures:
Fluorinated Compounds: Perfluoroalkyl substances (PFASs)
Health Outcomes:
Metabolic Outcomes: Obesity/body weight; DNA methylation
Biological Sample:
Blood; Cord blood; Hair; Urine
Other Participant Data:
Questionnaires; Cardiometabolic Risk Factors; Adipocytokines
Epigenetic Mechanisms Studied:
Peripheral blood leukocyte DNA methylation in cord blood and blood collected at 12 years of age
Abstract:

Related NIEHS-Funded Study Populations

Health Outcomes and Measures of the Environment (HOME) Study

Principal Investigator:
Lanphear, Bruce; Yolton, Kimberly; Cecil, Kim; Braun, Joseph; Chen, Aimin | Study Population Page Study Population c64
Institution:
Cincinnati Children’s Hospital Medical Center
Location:
Cincinnati, Ohio
Number of Participants::
468 Mothers and 479 children
Brief Description::
This is a pregnancy and birth cohort study in Cincinnati to evaluate the impact of low-level fetal and childhood chemical exposures on health, developmental, and neurobehavioral outcomes. The study recruited over 400 pregnant women between 2003 to 2006. Offspring have been followed to age 12 years.
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