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Internalizing Behaviors and Neuroimaging Outcomes: Impact of PBDE and PFC Exposures

Grant Number:
Principal Investigator:
Yolton, Kimberly; Cecil, Kim
Cincinnati Children's Hospital Medical Center
Most Recent Award Year:
Lifestage of Participants:
Exposure: Prenatal; Youth (1-18 years, specifically at 3-5, 8, and 11-12 years of age); Adulthood (mother)
Assessment: Youth (1-18 years, specifically at 11-12 years of age)
Brominated Compounds: Polybrominated diphenyl ethers (PBDEs)
Fluorinated Compounds: Perfluorinated compounds (PFCs)
Health Outcomes:
Mental Health Outcomes: Depression
Neurological/Cognitive Outcomes: Neurobehavioral outcomes; Neurodevelopmental outcomes
Biological Sample:
Serum; Urine
Other Participant Data:
Childhood symptoms of anxiety, depression, and social impairment; Neuroimaging to assess changes in anatomical structure, neurochemistry, organization of white matter tracts, and neural network connectivity

Related NIEHS-Funded Study Populations

Health Outcomes and Measures of the Environment (HOME) Study

Principal Investigator:
Lanphear, Bruce; Yolton, Kimberly; Cecil, Kim; Braun, Joseph; Chen, Aimin | Study Population Page Study Population c64
Cincinnati Children’s Hospital Medical Center
Cincinnati, Ohio
Number of Participants::
468 Mothers and 479 children
Brief Description::
This is a pregnancy and birth cohort study in Cincinnati to evaluate the impact of low-level fetal and childhood chemical exposures on health, developmental, and neurobehavioral outcomes. The study recruited over 400 pregnant women between 2003 to 2006. Offspring have been followed to age 12 years.
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