Grant Number:
Principal Investigator:
Perera, Frederica P
Institution:
Columbia University
Most Recent Award Year:
2007
Lifestage of Participants:
Exposure:
Prenatal; Youth (1-18 years)
Assessment:
Youth (1-18 years)
Exposures:
Air Pollutants:
Polycyclic aromatic hydrocarbons (PAHs)
Pesticides:
Organophosphates; Chlorpyrifos
Health Outcomes:
Metabolic Outcomes:
Obesity/body weight
Neurological/Cognitive Outcomes:
Neurobehavioral outcomes; Neurodevelopmental outcomes
Respiratory Outcomes:
Asthma
Biological Sample:
Urine
Environmental Sample:
Air sample
Other Participant Data:
Behavioral/Cognitive tests; Questionnaire; Lung function; Measures of airway inflammation
Abstract:
The major objective of the proposed research is to study the impact of early-life exposures to common urban pollutants on neurobehavioral development and asthma in a sample of children living in three low-income, minority communities of New York City (Central Harlem, Washington Heights and the South Bronx). Using a molecular epidemiologic approach with monitoring, biomarkers, and clinical assessments at serial time points, we will extend our study of African-American and Latina urban mothers and children in order to follow the cohort through child age 11 years to assess the longer-term impact of exposures on child health and developmental outcomes. The exposures of concern include airborne polycyclic aromatic hydrocarbons (PAH) and organophosphate pesticides such as chlorpyrifos (CPF). The first Specific Aim (Neurodevelopmental) builds on our prior findings and proposes to evaluate relationships between early exposures (PAHs and CPF) and longer-term neurodevelopment, in order to assess the persistence of neurotoxic effects into the school years, identify effects that may emerge over time, and delve more deeply into the behavioral domains to better understand the significance of behavior problems observed in the preschool years. The second aim (Asthma) also builds on our previous findings with respect to risk factors for asthma. We will repeat the assessment of immunoglobulin (lg)E at ages 5, 7, and 9 and obtain measures of lung function and airway inflammation, and a physician-diagnosis of asthma between ages 5 and 7 years. We will also assess the association between becoming overweight in the first 5 years of life and the development of IgE, airway inflammation, and asthma in childhood. The research will consider the effect of known determinants of disease and potential confounders, including other toxic exposures and demographic factors. By using a multidisciplinary approach to understand the complex pathogenesis of developmental disorders and asthma that impose such a heavy burden on inner-city children, we anticipate that the proposed research will have important implications for prevention.
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Related NIEHS-Funded Study Populations
New York City Mothers and Newborns Study
Principal Investigator:
Perera, Frederica
| Study Population Page Study Population c25
Institution:
Columbia University
Location:
New York, New York
Number of Participants::
~725 Mother-infant pairs
Brief Description::
This is a birth cohort study of minority mothers and children in New York City that examines the effects of early life exposures to air pollutants, environmental tobacco smoke, pesticides, and endocrine disrupting chemicals on children's neurodevelopment, respiratory health, growth, and development. The study has recruited approximately 725 pregnant mothers since 1998.