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Your Environment. Your Health.

Stress-Chemical Interactions and Neurobehavior in School Age Children

Grant Number:
Principal Investigator:
Wright, Robert O
Institution:
Icahn School of Medicine at Mount Sinai
Most Recent Award Year:
2017
Lifestage of Participants:
Exposure: Prenatal; Infant (0-1 year); Youth (1-18 years); Adulthood (mother)
Assessment: Infant (0-1 year); Youth (1-18 years, specifically 8-11 years of age)
Exposures:
Air Pollutants: Particulate matter (PM 2.5)
Metals: Arsenic; Cadmium; Chromium; Lead; Manganese; Nickel; Zinc; Barium; Strontium
Mixtures:
Non-Chemical Stress: Psychosocial stress
Health Outcomes:
Immune Outcomes: Inflammation
Metabolic Outcomes: Obesity/body weight
Neurological/Cognitive Outcomes: Neurodevelopmental outcomes; Inhibitory control
Biological Sample:
Cord blood; Deciduous teeth
Other Participant Data:
Inhibitory control using selective attention, self-control, cognitive inhibition; Cortisol rhythms for child and mother; Body mass index, bioimpedance, skin folds; Maternal psychosocial stress (lifetime trauma, current negative life events, depression)
Epigenetic Mechanisms Studied:
Mitochondrial DNA damage
Abstract:

Related NIEHS-Funded Study Populations

Early Life Exposures in Mexico to Environmental Toxicants (ELEMENT)

Principal Investigator:
Hu, Howard; Peterson, Karen; Hernandez-Avila, Mauricio; Tellez-Rojo, Martha Maria | Study Population Page Study Population c49
Institution:
University of Michigan
Location:
Mexico City, Mexico
Number of Participants::
1,653
Brief Description::
This is a group of three sequentially-enrolled, on-going, epidemiologic birth cohort studies in Mexico City with an original aim to investigate the impact of lead on child development. The research aims have since expanded to include a wide range health outcomes and environmental, nutritional, behavioral, genetic, and epigenetic risk factors. More than 1,600 mother-child pairs enrolled in the study beginning in 1994, some of whom have been followed for over two decades.
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