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Methylomic and Genomic Impacts of Organic Pollutants in Dup15q Syndrome

Grant Number:
Principal Investigator:
Lasalle, Janine M
University of California, Davis
Most Recent Award Year:
Lifestage of Participants:
Exposure: Prenatal; Adulthood (mother)
Assessment: Adulthood (mother); Youth (1-18 years)
Chlorinated Compounds: PCBs, PCB-95
Health Outcomes:
Neurological/Cognitive Outcomes: Autism spectrum disorder (ASD); Neurodevelopmental outcomes
Biological Sample:
Placenta; Teeth
Other Participant Data:
Maternal obesity as a co-exposure
Genes or Other DNA Products Studied:
Autism candidate genes with synaptic functions, UBE3A, Histone H2A.Z, Chromosome 15q11-q13 (Dup15q)
Epigenetic Mechanisms Studied:
DNA Methylation, Histone Marks

Related NIEHS-Funded Study Populations

Markers of Autism Risk in Babies-Learning Early Signs (MARBLES)

Principal Investigator:
University of California, Davis
Sacramento-Davis Area, California
Number of Participants::
~450 Mother-child pairs
Brief Description::
This is a longitudinal study investigating perinatal biological and environmental risk factors of autism among women who have a biological child with autism.
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