Skip Navigation

Epigenetics of Imprinted Genes in Children with Prenatal Phthalate Exposure

Grant Number:
Principal Investigator:
Tindula, Gwen
University of California, Berkeley
Most Recent Award Year:
Lifestage of Participants:
Exposure: Prenatal (specifically at 13 and 26 weeks gestation); Adulthood (mother); Adulthood (father)
Assessment: Adulthood (mother); Infant (0-1 year)
Personal Care/Consumer Products: Phthalates
Health Outcomes:
Birth Outcomes: Birthweight; Gestational age
Metabolic Outcomes: Obesity/body weight
Biological Sample:
Cord blood; Urine (mother)
Other Participant Data:
Tracking newborn sex, maternal gestational weight gain, maternal and paternal BMI, ancestry, and cord blood cell composition
Epigenetic Mechanisms Studied:
DNA methylation of imprinted genes in cord blood samples

Related NIEHS-Funded Study Populations

Newborn Epigenetics Study Cohort (NEST)

Principal Investigator:
Hoyo, Cathrine; Murphy, Susan | Study Population Page Study Population c178
Duke University
Durham, North Carolina
Number of Participants::
2,500 Mother-Infant Pairs
Brief Description::
This is a birth cohort study investigating how early life environmental exposures and nutrition affect DNA methylation profiles in newborns. Infants were followed throughout early childhood to determine if methylation profiles established in utero are associated with childhood obesity and neurobehavioral outcomes. Since 2004, NEST has enrolled more than 2,500 women in central North Carolina.

Center for the Health Assessment of Mothers and Children of Salinas (CHAMACOS)

Principal Investigator:
University of California, Berkeley
Salinas, California
Number of Participants::
~600 Mother-infant pairs
Brief Description::
This is a pregnancy study examining the effects, including the cumulative effects, of chemicals and other factors in the environment on children’s health among pregnant women and children living in the Salinas Valley, California. This study has enrolled approximately 600 participants since 1999.
to Top