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Your Environment. Your Health.

The Michigan PBB Cohort: A Unique, Highly Exposed Community Followed for 45 Years and Three Generations

Grant Number:
Principal Investigator:
Marcus, Michele
Emory University
Most Recent Award Year:
Lifestage of Participants:
Exposure: Prenatal; Infant (0-1 year); Adulthood (18+ years); Transgenerational
Assessment: Infant (0-1 year); Youth (1-18 years); Adulthood (18+ years)
Brominated Compounds: Polybrominated biphenyls (PBBs)
Flame Retardants:
Persistent organic pollutants (POPs):
Health Outcomes:
Biological Sample:
Blood; Semen; Urine
Other Participant Data:
Death certificate data, cancer registry data
Epigenetic Mechanisms Studied:
EWAS, age acceleration, stochastic epimutations

Related NIEHS-Funded Study Populations

Michigan PBB Cohort

Principal Investigator:
Emory University
Number of Participants::
Brief Description::
This is a multi-generational cohort study to assess the effects of polybrominated biphenyl (PBB) exposure on a number of outcomes in men and women and their offspring after a widespread exposure incident in 1973. The Michigan PBB Registry was established in 1976 and enrolled approximately 4,000 farmers, chemical workers, and others with PBB exposure risk; children and grandchildren of original registrants have also been enrolled.
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