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Your Environment. Your Health.

In-Utero Exposures and Deregulation of IGF2

Grant Number:
Principal Investigator:
Hoyo, Cathrine
Duke University
Most Recent Award Year:
Lifestage of Participants:
Exposure: Prenatal; Adulthood (mother)
Assessment: Prenatal
Air Pollutants: Tobacco smoke
Health Outcomes:
Metabolic Outcomes: Obesity/body weight
Biological Sample:
Blood (mother); Cord blood; Saliva/buccal cells
Other Participant Data:
Questionnaire on sociodemographic data, smoking of cigarettes and other substances, dietary supplementation, use of assisted reproduction, and medical management during pregnancy obtained via medical records form (which can also be shared). Detailed parturition data were obtained including dose, duration and type of anesthesia used.
Genes or Other DNA Products Studied:
Developed assays to measuring methylation using pyrosequencing and measured it in ~400 cord blood DNA samples.
Epigenetic Mechanisms Studied:
DNA Methylation and gene expression

Related NIEHS-Funded Study Populations

Newborn Epigenetics Study Cohort (NEST)

Principal Investigator:
Hoyo, Cathrine; Murphy, Susan | Study Population Page Study Population c178
Duke University
Durham, North Carolina
Number of Participants::
2,500 Mother-Infant Pairs
Brief Description::
This is a birth cohort study investigating how early life environmental exposures and nutrition affect DNA methylation profiles in newborns. Infants were followed throughout early childhood to determine if methylation profiles established in utero are associated with childhood obesity and neurobehavioral outcomes. Since 2004, NEST has enrolled more than 2,500 women in central North Carolina.
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