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Early Life Phthalate and Perfluoroalkyl Substance Exposures and Childhood Bone Health

Grant Number:
Principal Investigator:
Buckley, Jessie P
Johns Hopkins University
Most Recent Award Year:
Lifestage of Participants:
Exposure: Prenatal; Youth (1-18 years, specifically early childhood, mid childhood, early adolescence); Adulthood (mother)
Assessment: Infant (0-1 years, specifically at birth); Youth (1-18 years, specifically at 8 and 12 years of age)
Fluorinated Compounds: Perfluoroalkyl substances (PFASs)
Nutrition/Diet/Supplements: Vitamin D; Calcium
Personal Care/Consumer Products: Phthalates
Health Outcomes:
Growth: Skeletal growth
Musculoskeletal Outcomes: Bone density; Bone strength
Biological Sample:
Serum; Urine
Other Participant Data:
Skeletal development using growth curve modeling; bone density using dual-energy X-ray absorptiometry (in related study); height; vitamin D biomarker concentrations to asses vitamin D metabolism, calcium intake

Related NIEHS-Funded Study Populations

Health Outcomes and Measures of the Environment (HOME) Study

Principal Investigator:
Lanphear, Bruce; Yolton, Kimberly; Cecil, Kim; Braun, Joseph; Chen, Aimin | Study Population Page Study Population c64
Cincinnati Children’s Hospital Medical Center
Cincinnati, Ohio
Number of Participants::
468 Mothers and 479 children
Brief Description::
This is a pregnancy and birth cohort study in Cincinnati to evaluate the impact of low-level fetal and childhood chemical exposures on health, developmental, and neurobehavioral outcomes. The study recruited over 400 pregnant women between 2003 to 2006. Offspring have been followed to age 12 years.
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