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Genetic Susceptibility to Cardiovascular Effects of Arsenic Exposure

Grant Number:
Principal Investigator:
Chen, Yu
Institution:
New York University
Most Recent Award Year:
2009
Lifestage of Participants:
Exposure: Adulthood (18+ years)
Assessment: Adulthood (18+ years)
Exposures:
Metals: Arsenic
Health Outcomes:
Cardiovascular Outcomes: Cardiovascular disease; Coronary artery disease
Biological Sample:
Serum; Urine
Environmental Sample:
Drinking water sample
Other Participant Data:
Intima-medial thickness as measure of atherosclerosis
Genes or Other DNA Products Studied:
Genes related to arsenic methylation (GSTM1, GSTT1, GSTO1, GSTP1, MTHFR, and AS3MT genes), oxidative stress (NOS3, SOD2, and CYBA), and inflammation and endothelial dysfunction (TNF, IL6, ICAM1, and VCAM1)
Abstract:

Related NIEHS-Funded Study Populations

Health Effects of Arsenic Longitudinal Study (HEALS)

Principal Investigator:
Ahsan, Habibul; Graziano, Joseph | Study Population Page Study Population c63
Institution:
University of Chicago
Location:
Araihazar, Bangladesh
Number of Participants::
~35,000 recruited; Recruitment goal of 50,000
Brief Description::
This large prospective cohort study is based on individual-level data from a population exposed to a wide range of inorganic arsenic from drinking water in Araihazar, Bangladesh. Since 2000, the study has recruited more than 35,000 men and women with extensive questionnaire data, biological samples, drinking water samples, and diagnostic/clinical data.
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