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Prenatal Exposure to Polyfluoroalkyl Chemicals (PFCs) and Child Growth and Development

Grant Number:
Principal Investigator:
Sagiv, Sharon K
University of California, Berkeley
Most Recent Award Year:
Lifestage of Participants:
Exposure: Prenatal; Infant (0-1 year); Youth (1-18 years, specifically at 7 years of age); Adulthood (18+ years, specifically to 19 years of age); Adulthood (mother)
Assessment: Infant (0-1 year); Youth (1-18 years, specifically 1-7 years of age); Adulthood (18+ years, specifically to 19 years of age)
Fluorinated Compounds: Perfluorooctanoic acid (PFOA); Perfluorooctanesulfonic acid (PFOS); Perfluorohexane sulfonate (PFHxS); Perfluorononanoate (PFNA)
Health Outcomes:
Birth Outcomes: Birthweight; Head circumference
Metabolic Outcomes: Diabetes; Thyroid dysfunction
Neurological/Cognitive Outcomes: Attention deficit hyperactivity disorder (ADHD); Neurodevelopmental outcomes; Cognition; Behavior
Biological Sample:
Plasma (mother, child)
Other Participant Data:
Child serum lipids (including total, HDL and LDL cholesterol) and insulin resistance; Child blood pressure; Cognitive tests (visual memory, visual motor ability, language, intelligence, and executive function); Maternal thyroid hormone levels

Related NIEHS-Funded Study Populations

Project Viva

Principal Investigator:
Oken, Emily; Hivert, Marie-France | Study Population Page Study Population c204
Harvard Pilgrim Health Care Institute
Eastern Massachusetts
Number of Participants::
2,128 mother-child pairs
Brief Description::
This is a longitudinal pre-birth cohort study originally designed to examine the effects of maternal diet, air pollution, and other environmental factors, on child growth and development. In 1999-2002, 2,128 mother-child pairs in eastern Massachusetts were enrolled in the study. Mother and child follow-up is ongoing.
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