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Your Environment. Your Health.

Nutrition, Deregulation of Imprinted Genes

Grant Number:
Principal Investigator:
Hoyo, Cathrine
Duke University
Most Recent Award Year:
Lifestage of Participants:
Exposure: Prenatal; Infant (0-1 year); Youth (1-18 years, specifically 1-3 years of age); Adulthood (mother)
Assessment: Youth (1-18 years, specifically 1-3 years of age)
Nutrition/Diet/Supplements: B vitamins (folate, vitamins B12 and B6)
Health Outcomes:
Metabolic Outcomes: Obesity/aberrant body weight
Biological Sample:
Blood; Saliva/buccal cells
Other Participant Data:
Maternal diet data; Infant weight and height
Genes or Other DNA Products Studied:
Insulin-like growth factor-2 (IGF2); Delta, drosophila homolog-like-1 (DLK1)
Epigenetic Mechanisms Studied:
DNA Methylation

Related NIEHS-Funded Study Populations

Newborn Epigenetics Study Cohort (NEST)

Principal Investigator:
Hoyo, Cathrine; Murphy, Susan | Study Population Page Study Population c178
Duke University
Durham, North Carolina
Number of Participants::
2,500 Mother-Infant Pairs
Brief Description::
This is a birth cohort study investigating how early life environmental exposures and nutrition affect DNA methylation profiles in newborns. Infants were followed throughout early childhood to determine if methylation profiles established in utero are associated with childhood obesity and neurobehavioral outcomes. Since 2004, NEST has enrolled more than 2,500 women in central North Carolina.
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