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Animal Models Confirm Drug DES' Role in Abnormal Development of Offspring

child reaching up toward man and preganant woman

Scientists developed an animal model that predicts and confirms that exposure to Diethylstilbestrol (DES), a drug that was prescribed during pregnancy for women from 1938 to 1971 to prevent miscarriages and premature deliveries, can result in various reproductive abnormalities in both male and female offspring. NIEHS children's health researchers have continued to expand research linking early environmental exposures to adult diseases.

Tags: children's health, women's health


Bibbo M, Al-Naqeeb M, Baccarini I, Gill W, Newton M, Sleeper KM, Sonek RN, Wied GL. 1975. Follow-up study of male and female offspring of DES-treated mothers a preliminary report. J Reprod Med 15(1):29-32. [Abstract]

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