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(http://www.niehs.nih.gov//portfolio/index.cfm?do=portfolio.grantdetail&&grant_number=F31ES035618&format=word)
| Principal Investigator: Marian, Brittney | |
|---|---|
| Institute Receiving Award | University Of Southern California |
| Location | Los Angeles, CA |
| Grant Number | F31ES035618 |
| Funding Organization | National Institute of Environmental Health Sciences |
| Award Funding Period | 01 Jan 2024 to 31 Dec 2025 |
| DESCRIPTION (provided by applicant): | PROJECT SUMMARY/ABSTRACT Air pollution exposure is a universal concern linked to a wide range of adverse health outcomes. Ambient air pollution is a complex environmental exposure arising from numerous different sources and varies over time; however, many air pollution health effects studies fail to consider more than a single pollutant at a time and rely on an exposure that has been averaged over time. Recent advancements in statistical methodologies for multi- collinear exposures have resulted in an increased number of studies on human health impacts of multipollutant mixtures, but these methodologies still often result in hard-to-interpret effect estimates and do not extend to repeated measures of exposure. Thus, there is a need to further improve mixtures methodologies to be able to investigate time-varying exposures and have interpretable exposure effect estimates. The overall goal of this study is to improve methodologies for the study of air pollution mixtures by using a two-stage time series clustering approach. Initial work focuses on supplementing current literature by extending clustering methodologies to the interpretable analysis of time series data. This developmental work will provide a strong foundation for later application to identify and translate multipollutant diurnal exposure profiles. In Aim 1, I will identify the optimal number of ending clusters by extending current methods on static data and evaluating their performance on time series data. Identification of optimal cluster number is nontrivial without external information (e.g., a key) and current methods fail to provide evidence of positive (or negative) performance for time series data. In Aim 2, I will extend the linear statistical model to appropriately translate multivariate clustering methods to studies on health effects of pollutant mixtures. Exposures grouped by clusters are themselves visually intuitive but would be improved by adding interpretive distances between features of the representative cluster center and individual cluster members. The time series clustering methodology will be demonstrated in two applications: (Aim 3a) to identify typical multipollutant diurnal profiles in Southern California, and (Aim 3b) to evaluate their associations with exhaled nitric oxide (FeNO) in the Southern California Children’s Health Study. Hourly monitoring data for particulate matter <2.5µm (PM2.5) and <10µm (PM10), nitrogen dioxide (NO2), and ozone (O3) are used to identify typical diurnal ambient air pollution exposures and relate them to pediatric health. This work will improve current mixtures methods and provide new tools for the study of time-varying exposures. The analysis of time-varying exposures is of increasing import with the growing amounts of data in response to recent technological advances. Time-varying mixtures are present in many places (e.g., air, soil) and development of applicable methodologies would benefit public health and regulatory decisions. |
| Science Code(s)/Area of Science(s) |
Primary: 81 - Statistics/Statistical Methods/Development Secondary: 03 - Carcinogenesis/Cell Transformation |
| Publications | No publications associated with this grant |
| Program Officer | Bonnie Joubert |