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(http://www.niehs.nih.gov//portfolio/index.cfm?do=portfolio.grantdetail&&grant_number=P30ES023515&format=word)
| Principal Investigator: Wright, Robert O | |
|---|---|
| Institute Receiving Award | Icahn School Of Medicine At Mount Sinai |
| Location | New York, NY |
| Grant Number | P30ES023515 |
| Funding Organization | National Institute of Environmental Health Sciences |
| Award Funding Period | 18 Jun 2014 to 30 Apr 2028 |
| DESCRIPTION (provided by applicant): | Project Summary In the eight years since its inception, the Mount Sinai P30 Center on Health and Environment Across the LifeSpan (HEALS) has greatly accelerated environmental health science (EHS) research. Using a life course approach and the underlying philosophy that environment plays an important role in all diseases, we have formed new transdisciplinary teams partnering with other Mount Sinai P30 Centers in Aging, Cancer, and Skin Biology, as well as our Clinical and Translational Science Award (CTSA), to bring environment into more research programs at Mount Sinai. We have prioritized diversity among Center Members, recruits, and trainees and linked scientists with cross-disciplinary backgrounds to address complex research questions. We expanded our NIEHS funding base—catapulting from 27th to 2nd in funding dollars—and more than tripled our overall funding. This growth, largely fueled by our Pilot Projects program, accelerated career development for our Center Scientists and other Members. The Center supports three Facility Cores: an Integrated Health Sciences Facility Core that supports biomarker research and access to clinical populations/biospecimens, a Biostatistics and Data Science Facility Core that supports analysis of environmental data and creates new data analytical methods needed for exposomic research; and a clinically-oriented Phenotyping and Environmental Modifier Facility Core that supports state-of-the-art measures of health and environmental modifiers (stress, nutrition, etc.). Our Community Engagement Core is committed to multi-directional communication and partners with diverse communities. These partnerships, along with strong links with physicians, enable us to effectively translate Center research findings into evidence-based approaches for disease prevention and treatment. In the next funding cycle, the Center will continue to build capacity, new research programs, and expand further into each of the Core areas. With outstanding institutional support through our Institute for Exposomics Research and ties to our CTSA, we will bring EHS into all Mount Sinai research programs. In line with this goal, we anticipate a need for additional human resources and physical infrastructure to increase Facility Core capacity and to remain at the cutting edge of exposure science and EHS—the Center is essential to meet these needs. Finally, our program aligns with NIEHS strategic goals: our Research Groups (Exposomics-Mixtures, Environmental Justice, and Clinical Environmental Research) emphasize the study of multiple exposures working via multiple mechanisms and move EHS toward health equity research and precision medicine initiatives. The Center also emphasizes shared biological pathways of exposures, individual susceptibility, exposomics, environmental causes of disease, and community engagement, all of which are central to NIEHS's mission. In closing, its remarkable success to date positions the HEALS Center for expanded reach and impact through continuing to meet the changing infrastructure needs of our environmental research community to accelerate EHS discovery and translation. |
| Science Code(s)/Area of Science(s) |
Primary: 31 - Environmental Health Sciences Centers Secondary: - |
| Publications | See publications associated with this Grant. |
| Program Officer | Claudia Thompson |