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(http://www.niehs.nih.gov//portfolio/index.cfm?do=portfolio.grantdetail&&grant_number=P42ES033719&format=word)
| Principal Investigator: Navas-Acien, Ana | |
|---|---|
| Institute Receiving Award | Columbia University Health Sciences |
| Location | New York, NY |
| Grant Number | P42ES033719 |
| Funding Organization | National Institute of Environmental Health Sciences |
| Award Funding Period | 21 Sep 2022 to 30 Jun 2027 |
| DESCRIPTION (provided by applicant): | Summary Tribal lands are impacted by more than 15,000 hazardous waste sites and 7,000 abandoned mines that can disrupt the redox chemistry of aquifers and release toxic metals. In collaboration with tribal communities from North/South Dakota, we found that arsenic (As) and uranium (U) affect drinking water in private wells and rural water systems in the Northern Plains. Our data also show that in the 1990s/early 2000s Native Americans from the Northern Plains experienced urinary As and U levels 2.5 to 5 times higher than other US populations, likely contributing to a high burden of cardiovascular disease. Knowledge is needed on current metal exposure levels, sources (local and distal), health effects (concurrent, latent, joint), mechanistic pathways, and effective remediation systems. To address these scientific and technology gaps, we have established the Columbia University Northern Plains Superfund Research Program. This new partnership has five Projects and four Cores and will use systems science, local knowledge, and innovative technology through the following aims: (1) Develop household-level spatial and temporal models of groundwater metal concentrations integrating new measures of water As, U, and redox parameters with USGS and IHS data. These models can identify safe water vs. where mitigation interventions are needed. (2) Trace sources and cycling of metals in water and biological specimens through stable isotope measurements (U, Se) to reveal redox state and inform on local and distal sources of contamination, directly addressing our communities’ concern. (3) Determine latent and concurrent cardiometabolic effects of As and U in humans (Strong Heart As/U Lifelong study, SHAUL), and in human- relevant mouse models. These data will enhance the assessment of causality and the role of early life exposures. (4) Integrate molecular mechanisms of As and U toxicity using multi-omics (epigenomics, metabolomics) in longitudinal studies in humans (SHAUL) and mice. The cross-species comparison can identify robust signatures and mechanisms to help generate intervention strategies. (5) Develop sustainable interventions using light- based, point-of-use water remediation technology for As/U. This system will produce and recycle adsorption media with photosynthetic bacteria and alert residents before treatment failure. The Community Engagement Core will be centrally located in the Northern Plains, contributing to all research activities and local dissemination. The Data Management and Analysis and Administrative Cores will optimize use of the complex data generated while respecting tribal data sovereignty and promoting evidence-based policies and practices to address hazardous toxic metals and contribute to disease prevention. We will train the next generation of scientists in systems science, technology, Indigenous research ethics, and community outreach. The breadth, depth, and innovation of our approaches, the community’s central role, the institutional support, and our experience working together will lay the groundwork for interventions that address key concerns for water quality and human health in communities in the Northern Plains and near abandoned mines and Superfund sites. |
| Science Code(s)/Area of Science(s) |
Primary: 35 - Superfund Research Program Centers Secondary: 03 - Carcinogenesis/Cell Transformation |
| Publications | See publications associated with this Grant. |
| Program Officer | Danielle Carlin |