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(http://www.niehs.nih.gov//portfolio/index.cfm?do=portfolio.grantdetail&&grant_number=R24ES036135&format=word)
| Principal Investigator: Cheung, Kei-Hoi | |
|---|---|
| Institute Receiving Award | Yale University |
| Location | New Haven, CT |
| Grant Number | R24ES036135 |
| Funding Organization | National Institute of Environmental Health Sciences |
| Award Funding Period | 15 May 2024 to 28 Feb 2029 |
| DESCRIPTION (provided by applicant): | Project Summary Water contamination is one of the biggest public health concerns of the day. Chemical contamination of drinking water can lead to a wide range of chronic adverse health impacts including cancer and developmental, neurological, and reproductive damages. Populations worldwide are exposed to a myriad of chemicals, which have been recently classified as emerging contaminants (EC), via drinking water. These ECs originate from personal care products, pesticides, plastics, and a numerous array of emissions to the environment. Only a handful of ECs have been extensively evaluated regarding human exposures and health impacts. There is a paucity of knowledge on emergent water contaminants in terms of their impact on human health. Data-driven environmental health sciences (EHS) research brings hope to fill this knowledge gap. However, this hope will not be completely fulfilled if the data is not FAIR (findable, accessible, interoperable, and reusable). Without FAIR data, it would be very challenging to integrate diverse types of exposure related data that are heterogenous in format and structure and are difficult to find. To make data FAIR to enable integrative exposure studies, it involves the following objectives: i) open development, extension, adoption, and refinement of data and metadata standards, ii) software tools to implement standards, and iii) engagement with the stakeholders across different communities. This proposal leverages scientific use cases to engage with the EHS and data science communities to achieve these objectives. It assembles a multidisciplinary team of biomedical researchers, environmental science and engineering experts, and data scientists. The proposed use cases represent complementary types of EC exposure studies. We will utilize these use cases as a foundation to develop strategies to tackle the complex data integration challenge. It entails the following specific aims. 1. Creating rich machine-readable metadata as part of developing a minimum information standard for environmental exposure assessment. 2. Annotating, mapping, and extracting data with the use of ontologies and common data elements (CDEs) 3. Harmonizing exposure related data with a graph model to build an environmental exposure knowledge graph. 4. Engaging the user community through expert panels, workshops, social networking, and NIEHS-sponsored meetings. 5. Evaluating the impact of the proposed project using appropriate metrics including user surveys, assessment of data FAIRness, usability, and NLP evaluation metrics such as accuracy, precision, recall, and F-measures. |
| Science Code(s)/Area of Science(s) |
Primary: 73 - Bioinformatics/BISTI Related Secondary: 03 - Carcinogenesis/Cell Transformation |
| Publications | No publications associated with this grant |
| Program Officer | Christopher Duncan |