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Principal Investigator: Ford, Lance P
Institute Receiving Award Attogene
Location Austin, TX
Grant Number R43ES034301
Funding Organization National Institute of Environmental Health Sciences
Award Funding Period 07 Jul 2023 to 30 Jun 2025
DESCRIPTION (provided by applicant): Project Summary Dihydroanatoxin (dhATX) derived from cyanobacteria is a rapidly emerging global problem that negatively impacts human and animal health. Poisoning induced by dhATX is characterized by a broad array of neurological and cardiovascular symptoms with extremes of severity which can lead to fatality. Therefore, efficient, and effective detection, prevention, control, and mitigation technologies are critically needed to prevent exposures. The only available technology to detect the presence of dhATX is expensive, time consuming, and labor intensive, allowing only sporadic testing to be performed. This lack of rapid, simple, inexpensive testing capability increases the chances of human and animal exposures and associated health problems. Based on our current progress in developing rapid assays for environmental toxins, we will develop a rapid, quantitative, and cost- effective receptor binding assay for detecting dhATX in the field setting. Our test platform will likely emerge as an integral component of monitoring programs domestically and internationally to improve dhATX detection, and will provide an effective tool for public health officials to act quickly to reduce dhATX exposures.
Science Code(s)/Area of Science(s) Primary: 72 - Predictive Toxicology/Assay Development
Secondary: 03 - Carcinogenesis/Cell Transformation
Publications No publications associated with this grant
Program Officer Daniel Shaughnessy
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