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(http://www.niehs.nih.gov//portfolio/index.cfm?do=portfolio.grantdetail&&grant_number=U24ES036003&format=word)
| Principal Investigator: Woodruff, Tracey J. | |
|---|---|
| Institute Receiving Award | University Of California, San Francisco |
| Location | San Francisco, CA |
| Grant Number | U24ES036003 |
| Funding Organization | National Institute of Environmental Health Sciences |
| Award Funding Period | 04 Mar 2024 to 28 Feb 2029 |
| DESCRIPTION (provided by applicant): | ABSTRACT - Enriching a Diverse Pregnancy Cohort from the San Francisco Bay Area to Expand Data Access and Individual Results Return on Environmental Exposures to Participant Communities We seek to expand our Chemicals in Our Bodies (CIOB) pregnancy cohort at University of California, San Francisco (UCSF) to enhance the diversity of our study population, integrate new individual and neighborhood level measures of structural racism and social marginalization, expand environmental chemical exposure measures, report back individual chemical results to participants, and share accessible and actionable pregnancy cohort data to diverse end-users. CIOB is a diverse pregnancy cohort of Latina, White, Asian, and Black participants dedicated to understanding how prenatal exposures to endocrine-disrupting chemicals (EDCs) and social stressors during pregnancy affect perinatal, maternal health, and neurodevelopmental outcomes in offspring. With 769 participants, the nine-year-old CIOB pregnancy cohort was launched in the San Francisco Bay Area as part of our NIEHS/US EPA Children’s Environmental Health Center, and continued recruitment of pregnant participants and extended follow-up of offspring through seven years old in collaboration with University of Illinois Urbana-Champaign as part of the NIH ECHO program. For this grant, we will enhance the diversity of CIOB by expanding recruitment of Black (N=80) and other pregnant participants of color (N=70) from Oakland, CA (Total N=150) from a safety net hospital. We will administer our established surveys and collect biospecimens to increase our cohort size to ~920 participants and measure ~200 chemicals including phthalates and other plasticizers, phenolic compounds, pesticides, and aromatic amines. We will integrate new neighborhood measures of structural racism and socioeconomic marginalization to facilitate analyses of the cumulative and joint effects of chemical and social stressor exposures on perinatal and maternal health outcomes. We will evaluate the relationship between the multiple chemical exposures and social stressors and their relationship to adverse pregnancy outcomes. We will also make our cohort data broadly accessible to other researchers including those who wish to leverage banked biospecimens and expand analyses of prenatal social and environmental chemical exposures via the Vivli platform, an online data repository. We will use the smartphone Digital Exposure Report Back Interface (DERBI) to report back to participants their individual chemical exposure results (with aggregate study results, exposure sources, and strategies for individual and collective approaches to exposure reduction). Development of DERBI will entail iterative feedback from our participants via usability testing. Analyses using our CIOB cohort will inform clinical practice, as well as environmental and social policies and interventions to eliminate the double jeopardy of environmental chemical and social stressor exposures on perinatal and maternal health. |
| Science Code(s)/Area of Science(s) |
Primary: 97 - Partnerships for Environmental Public Health/Community Research Secondary: 03 - Carcinogenesis/Cell Transformation |
| Publications | No publications associated with this grant |
| Program Officer | Lindsey Martin |