Project Title: | ACTIVATION OF NRF2 DURING EMBRYONIC DEVELOPMENT - MECHANISMS AND CONSEQUENCES |
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PI: | Timme-Laragy, Alicia R |
Institution: | University Of Massachusetts Amherst |
Grant Number: | R01ES025748 |
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Publication Title | Authors | Grant Number(s) | Journal (Pub date) | PubMed Link | Pub Year |
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Developmental impacts of Nrf2 activation by dimethyl fumarate (DMF) in the developing zebrafish (Dan ... | Marques, Emily S; Severance, Emily G; Min, Bellis; Arsenault, Paige; Conlin, Sarah M; Timme-Lar ... | R01ES025748, R01ES025748 | Free Radic Biol Med (2023 Jan) | 36528121 | 2023 |
Dietary exposure to the food preservative tert-Butylhydroquinone (tBHQ) impairs zebrafish (Danio rer ... | Leonard, Emily R; Marques, Emily S; Roy, Monika A; Conlin, Sarah M; Ranjan, Ravi; Timme-Laragy, ... | R01ES025748, R01ES025748 | Food Chem Toxicol (2023 Jun) | 37075880 | 2023 |
Nrf2a dependent and independent effects of early life exposure to 3,3'-dichlorobiphenyl (PCB-11) in ... | Roy, Monika A; Gridley, Charlotte K; Li, Sida; Park, Yeonhwa; Timme-Laragy, Alicia R | P42ES013661, R01ES025748, R01ES025748 | Aquat Toxicol (2022 Aug) | 35700651 | 2022 |
Relationships between type 2 diabetes, cell dysfunction, and redox signaling: A meta-analysis of sin ... | Marques, Emily Sara; Formato, Emily; Liang, Wenle; Leonard, Emily; Timme-Laragy, Alicia R | P42ES027706, R01ES025748, R01ES025748 | J Diabetes (2022 Jan) | 34725923 | 2022 |
The Zebrafish (Danio rerio) Embryo Model as a Tool to Assess Drinking Water Treatment Efficacy for F ... | Roy, Monika A; Mohan, Aarthi; Karasik, Yankel; Tobiason, John E; Reckhow, David A; Timme-Laragy ... | R01ES025748, R01ES025748 | Environ Toxicol Chem (2022 Nov) | 36040130 | 2022 |
Developmental exposures to perfluorooctanesulfonic acid (PFOS) impact embryonic nutrition, pancreati ... | Sant, Karilyn E; Annunziato, Kate; Conlin, Sarah; Teicher, Gregory; Chen, Phoebe; Venezia, Oli ... | K01ES031640, K01ES031640, R01ES025748, R01ES025748 | Environ Pollut (2021 Apr 15) | 33581636 | 2021 |
Embryonic exposures to mono-2-ethylhexyl phthalate induce larval steatosis in zebrafish independent ... | Sant, Karilyn E; Moreau, Hadley M; Williams, Larissa M; Jacobs, Haydee M; Bowsher, Anna M; Bois ... | R01ES025748, R01ES025748 | J Dev Orig Health Dis (2021 02) | 32063256 | 2021 |
Maternal preconception PFOS exposure of Drosophila melanogaster alters reproductive capacity, develo ... | Kim, Ju Hyeon; Barbagallo, Belinda; Annunziato, Kate; Farias-Pereira, Renalison; Doherty, Jeffe ... | R01ES025748, R01ES025748 | Food Chem Toxicol (2021 May) | 33774094 | 2021 |
Modulating glutathione thiol status alters pancreatic β-cell morphogenesis in the developing zebrafi ... | Rastogi, Archit; Severance, Emily G; Jacobs, Haydee M; Conlin, Sarah M; Islam, Sadia T; Timme-L ... | R01ES025748, R01ES025748 | Redox Biol (2021 Jan) | 33321464 | 2021 |
Modulation of PPAR signaling disrupts pancreas development in the zebrafish, Danio rerio. | Venezia, Olivia; Islam, Sadia; Cho, Christine; Timme-Laragy, Alicia R; Sant, Karilyn E | K01ES031640, K01ES031640, R01ES025748, R01ES025748 | Toxicol Appl Pharmacol (2021 09 01) | 34302850 | 2021 |
Using Monochlorobimane to Visualize Glutathione Utilization in the Developing Zebrafish (Danio rerio ... | Rastogi, Archit; Timme-Laragy, Alicia R | R01ES025748, R01ES025748 | Curr Protoc (2021 Feb) | 33555621 | 2021 |
Chemical Characterization of a Legacy Aqueous Film-Forming Foam Sample and Developmental Toxicity in ... | Annunziato, Kate M; Doherty, Jeffery; Lee, Jonghwa; Clark, John M; Liang, Wenle; Clark, Christ ... | R01ES025748, R01ES025748, R25ES031498 | Environ Health Perspect (2020 Sep) | 32966100 | 2020 |
The sulfate metabolite of 3,3'-dichlorobiphenyl (PCB-11) impairs Cyp1a activity and increases hepati ... | Roy, Monika A; Duche, Perseverance R; Timme-Laragy, Alicia R | P42ES013661, R01ES025748, R01ES025748 | Chemosphere (2020 Dec) | 32693259 | 2020 |
Mapping glutathione utilization in the developing zebrafish (Danio rerio) embryo. | Rastogi, Archit; Clark, Christopher W; Conlin, Sarah M; Brown, Sarah E; Timme-Laragy, Alicia R | R01ES025748, R01ES025748 | Redox Biol (2019 09) | 31202080 | 2019 |
Perfluorobutanesulfonic Acid Disrupts Pancreatic Organogenesis and Regulation of Lipid Metabolism in ... | Sant, Karilyn E; Venezia, Olivia L; Sinno, Paul P; Timme-Laragy, Alicia R | R01ES025748, R01ES025748 | Toxicol Sci (2019 01 01) | 30239974 | 2019 |
The emerging contaminant 3,3'-dichlorobiphenyl (PCB-11) impedes Ahr activation and Cyp1a activity to ... | Roy, Monika A; Sant, Karilyn E; Venezia, Olivia L; Shipman, Alix B; McCormick, Stephen D; Saktr ... | P42ES013661, R01ES025748, R01ES025748 | Environ Pollut (2019 Nov) | 31421573 | 2019 |
Embryonic exposure to Mono(2-ethylhexyl) phthalate (MEHP) disrupts pancreatic organogenesis in zebra ... | Jacobs, Haydee M; Sant, Karilyn E; Basnet, Aviraj; Williams, Larissa M; Moss, Jennifer B; Timme ... | R01ES025748, R01ES025748, T32ES007062 | Chemosphere (2018 Mar) | 29277029 | 2018 |
Nrf2a modulates the embryonic antioxidant response to perfluorooctanesulfonic acid (PFOS) in the zeb ... | Sant, Karilyn E; Sinno, Paul P; Jacobs, Haydee M; Timme-Laragy, Alicia R | R01ES025748, R01ES025748 | Aquat Toxicol (2018 May) | 29524743 | 2018 |
Pancreatic beta cells are a sensitive target of embryonic exposure to butylparaben in zebrafish (Dan ... | Brown, Sarah E; Sant, Karilyn E; Fleischman, Shana M; Venezia, Olivia; Roy, Monika A; Zhao, Li ... | R01ES025748, R01ES025748 | Birth Defects Res (2018 07 03) | 29516647 | 2018 |
Redox stress and signaling during vertebrate embryonic development: Regulation and responses. | Timme-Laragy, Alicia R; Hahn, Mark E; Hansen, Jason M; Rastogi, Archit; Roy, Monika A | R01ES025748, R01ES025748 | Semin Cell Dev Biol (2018 08) | 28927759 | 2018 |
Zebrafish as a Model for Toxicological Perturbation of Yolk and Nutrition in the Early Embryo. | Sant, Karilyn E; Timme-Laragy, Alicia R | R01ES025748, R01ES025748 | Curr Environ Health Rep (2018 Mar) | 29417450 | 2018 |
Applying evolutionary genetics to developmental toxicology and risk assessment. | Leung, Maxwell C K; Procter, Andrew C; Goldstone, Jared V; Foox, Jonathan; DeSalle, Robert; Mat ... | R01ES025748, R01ES025748 | Reprod Toxicol (2017 Apr) | 28267574 | 2017 |
Embryonic exposures to perfluorooctanesulfonic acid (PFOS) disrupt pancreatic organogenesis in the z ... | Sant, Karilyn E; Jacobs, Haydee M; Borofski, Katrina A; Moss, Jennifer B; Timme-Laragy, Alicia ... | R01ES025748, R01ES025748 | Environ Pollut (2017 Jan) | 27810111 | 2017 |
Assessment of Toxicological Perturbations and Variants of Pancreatic Islet Development in the Zebraf ... | Sant, Karilyn E; Jacobs, Haydee M; Xu, Jiali; Borofski, Katrina A; Moss, Larry G; Moss, Jennif ... | R01ES025748, R01ES025748 | Toxics (2016 Sep) | 28393070 | 2016 |