| Project Title: | DETECTING MUTATIONAL SIGNATURES OF ENVIRONMENTAL MUTAGENS IN HEATHY INDIVIDUALS FOR PERSONALIZED CANCER PREVENTION |
|---|---|
| PI: | Alexandrov, Ludmil B |
| Institution: | University Of California, San Diego |
| Grant Number: | R01ES032547 |
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| Publication Title | Authors | Grant Number(s) | Journal (Pub date) | PubMed Link | Pub Year |
|---|---|---|---|---|---|
| APOBEC3B regulates R-loops and promotes transcription-associated mutagenesis in cancer. | McCann, Jennifer L; Cristini, Agnese; Law, Emily K; Lee, Seo Yun; Tellier, Michael; Carpenter, ... | R01ES030993, R01ES032547 | Nat Genet (2023 Oct) |
37735199
|
2023 |
| Assigning mutational signatures to individual samples and individual somatic mutations with SigProfi ... | Díaz-Gay, Marcos; Vangara, Raviteja; Barnes, Mark; Wang, Xi; Islam, S M Ashiqul; Vermes, Ian; ... | R01ES030993, R01ES032547 | bioRxiv (2023 Jul 11) |
37502962
|
2023 |
| Chromosomal fragile site breakage by EBV-encoded EBNA1 at clustered repeats. | Li, Julia Su Zhou; Abbasi, Ammal; Kim, Dong Hyun; Lippman, Scott M; Alexandrov, Ludmil B; Cleve ... | R01ES030993, R01ES032547 | Nature (2023 Apr) |
37046091
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2023 |
| Comprehensive analysis of mutational signatures reveals distinct patterns and molecular processes ac ... | Thatikonda, Venu; Islam, S M Ashiqul; Autry, Robert J; Jones, Barbara C; Gröbner, Susanne N; Wa ... | R01ES030993, R01ES032547 | Nat Cancer (2023 Feb) |
36702933
|
2023 |
| Control-independent mosaic single nucleotide variant detection with DeepMosaic. | Yang, Xiaoxu; Xu, Xin; Breuss, Martin W; Antaki, Danny; Ball, Laurel L; Chung, Changuk; Shen, ... | R01ES032547 | Nat Biotechnol (2023 Jun) |
36593400
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2023 |
| DNA damage and somatic mutations in mammalian cells after irradiation with a nail polish dryer. | Zhivagui, Maria; Hoda, Areebah; Valenzuela, Noelia; Yeh, Yi-Yu; Dai, Jason; He, Yudou; Nandi, ... | R01ES030993, R01ES032547, R35ES031638 | Nat Commun (2023 Jan 17) |
36650165
|
2023 |
| Extrachromosomal DNA in the cancerous transformation of Barrett's oesophagus. | Luebeck, Jens; Ng, Alvin Wei Tian; Galipeau, Patricia C; Li, Xiaohong; Sanchez, Carissa A; Katz ... | R01ES032547 | Nature (2023 Apr) |
37046089
|
2023 |
| Mitotic tethering enables inheritance of shattered micronuclear chromosomes. | Trivedi, Prasad; Steele, Christopher D; Au, Franco K C; Alexandrov, Ludmil B; Cleveland, Don W | R01ES030993, R01ES032547 | Nature (2023 Jun) |
37316668
|
2023 |
| Topography of mutational signatures in human cancer. | Otlu, Burçak; Díaz-Gay, Marcos; Vermes, Ian; Bergstrom, Erik N; Zhivagui, Maria; Barnes, Mark; ... | R01ES030993, R01ES032547 | Cell Rep (2023 Aug 29) |
37540596
|
2023 |
| Unraveling the impact of a germline heterozygous POLD1 frameshift variant in serrated polyposis synd ... | Bonjoch, Laia; Soares de Lima, Yasmin; Díaz-Gay, Marcos; Dotti, Isabella; Muñoz, Jenifer; Morei ... | R01ES032547 | Front Mol Biosci (2023) |
36756361
|
2023 |
| Visualizing and exploring patterns of large mutational events with SigProfilerMatrixGenerator. | Khandekar, Azhar; Vangara, Raviteja; Barnes, Mark; Díaz-Gay, Marcos; Abbasi, Ammal; Bergstrom, ... | R01ES030993, R01ES032547 | BMC Genomics (2023 Aug 21) |
37605126
|
2023 |
| An overview of mutational and copy number signatures in human cancer. | Steele, Christopher D; Pillay, Nischalan; Alexandrov, Ludmil B | R01ES030993, R01ES032547 | J Pathol (2022 Jul) |
35420163
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2022 |
| Examining clustered somatic mutations with SigProfilerClusters. | Bergstrom, Erik N; Kundu, Mousumy; Tbeileh, Noura; Alexandrov, Ludmil B | R01ES030993, R01ES032547 | Bioinformatics (2022 Jun 27) |
35595234
|
2022 |
| Mapping clustered mutations in cancer reveals APOBEC3 mutagenesis of ecDNA. | Bergstrom, Erik N; Luebeck, Jens; Petljak, Mia; Khandekar, Azhar; Barnes, Mark; Zhang, Tongwu; ... | R01ES030993, R01ES032547 | Nature (2022 Feb) |
35140399
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2022 |
| Mechanisms of APOBEC3 mutagenesis in human cancer cells. | Petljak, Mia; Dananberg, Alexandra; Chu, Kevan; Bergstrom, Erik N; Striepen, Josefine; von Morg ... | R01ES030993, R01ES032547 | Nature (2022 Jul) |
35859169
|
2022 |
| Signatures of copy number alterations in human cancer. | Steele, Christopher D; Abbasi, Ammal; Islam, S M Ashiqul; Bowes, Amy L; Khandekar, Azhar; Haase ... | R01ES030993, R01ES032547 | Nature (2022 Jun) |
35705804
|
2022 |
| Uncovering novel mutational signatures by de novo extraction with SigProfilerExtractor. | Islam, S M Ashiqul; Díaz-Gay, Marcos; Wu, Yang; Barnes, Mark; Vangara, Raviteja; Bergstrom, Er ... | R01ES032547 | Cell Genom (2022 Nov 09) |
36388765
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2022 |
| Genomic and evolutionary classification of lung cancer in never smokers. | Zhang, Tongwu; Joubert, Philippe; Ansari-Pour, Naser; Zhao, Wei; Hoang, Phuc H; Lokanga, Rache ... | R01ES032547 | Nat Genet (2021 09) |
34493867
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2021 |
| Significance and limitations of the use of next-generation sequencing technologies for detecting mut ... | Abbasi, Ammal; Alexandrov, Ludmil B | R01ES030993, R01ES032547 | DNA Repair (Amst) (2021 Nov) |
34411908
|
2021 |