| Project Title: | DEVELOPING METABOLOMIC TECHNOLOGIES TO ADVANCE ENVIRONMENTAL EXPOSURE ANALYSIS |
|---|---|
| PI: | Patti, Gary J |
| Institution: | Washington University |
| Grant Number: | R35ES028365 |
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Viewing 63 publications
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| Publication Title | Authors | Grant Number(s) | Journal (Pub date) | PubMed Link | Pub Year |
|---|---|---|---|---|---|
| 13C-SpaceM: Spatial single-cell isotope tracing reveals heterogeneity of de novo fatty acid synthesi ... | Buglakova, Elena; Ekelöf, Måns; Schwaiger-Haber, Michaela; Schlicker, Lisa; Molenaar, Martijn R ... | R35ES028365 | bioRxiv (2024 Feb 28) |
38464218
|
2024 |
| Discovery and Identification of Three Homocysteine Metabolites by Chemical Derivatization and Mass S ... | Agongo, Julius; Grady, Scott F; Cho, Kevin; Patti, Gary J; Bythell, Benjamin J; Arnatt, Christ ... | R35ES028365 | Anal Chem (2024 Jul 23) |
38976774
|
2024 |
| Inducing vulnerability to InhA inhibition restores isoniazid susceptibility in drug-resistant Mycoba ... | Harrison, Gregory A; Wang, Erin R; Cho, Kevin; Mreyoud, Yassin; Sarkar, Souvik; Almqvist, Fred ... | R35ES028365 | mBio (2024 Mar 13) |
38294237
|
2024 |
| Introducing 'identification probability' for automated and transferable assessment of metabolite ide ... | Metz, Thomas O; Chang, Christine H; Gautam, Vasuk; Anjum, Afia; Tian, Siyang; Wang, Fei; Colby ... | R35ES028365 | bioRxiv (2024 Jul 31) |
39131324
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2024 |
| Loss of mitochondrial pyruvate transport initiates cardiac glycogen accumulation and heart failure. | Weiss, Rachel C; Pyles, Kelly D; Cho, Kevin; Brennan, Michelle; Fisher, Jonathan S; Patti, Gar ... | R35ES028365 | bioRxiv (2024 Jun 09) |
38895296
|
2024 |
| Metabolite Study and Structural Authentication for the First-in-Human Use Sphingosine-1-phosphate Re ... | Qiu, Lin; Jiang, Hao; Cho, Kevin; Yu, Yanbo; Jones, Lynne A; Huang, Tianyu; Perlmutter, Joel ... | R35ES028365 | ACS Chem Neurosci (2024 May 01) |
38634759
|
2024 |
| Spatial single-cell isotope tracing reveals heterogeneity of de novo fatty acid synthesis in cancer. | Buglakova, Elena; Ekelöf, Måns; Schwaiger-Haber, Michaela; Schlicker, Lisa; Molenaar, Martijn R ... | R35ES028365 | Nat Metab (2024 Sep) |
39251875
|
2024 |
| Cytosolic and mitochondrial NADPH fluxes are independently regulated. | Niu, Xiangfeng; Stancliffe, Ethan; Gelman, Susan J; Wang, Lingjue; Schwaiger-Haber, Michaela; R ... | R35ES028365 | Nat Chem Biol (2023 Jul) |
36973440
|
2023 |
| Effects of hepatic mitochondrial pyruvate carrier deficiency on de novo lipogenesis and gluconeogene ... | Yiew, Nicole K H; Deja, Stanislaw; Ferguson, Daniel; Cho, Kevin; Jarasvaraparn, Chaowapong; Jac ... | R35ES028365 | iScience (2023 Nov 17) |
37942005
|
2023 |
| Effects of hepatic mitochondrial pyruvate carrier deficiency on de novo lipogenesis and glycerol-med ... | Yiew, Nicole K H; Deja, Stanislaw; Ferguson, Daniel; Cho, Kevin; Jarasvaraparn, Chaowapong; Jac ... | R35ES028365 | bioRxiv (2023 Aug 24) |
36824879
|
2023 |
| Hyperammonaemia disrupts daily rhythms reversibly by elevating glutamate in the central circadian pa ... | Granados-Fuentes, Daniel; Cho, Kevin; Patti, Gary J; Costa, Rodolfo; Herzog, Erik D; Montagnese ... | R35ES028365 | Liver Int (2023 Mar) |
36367321
|
2023 |
| Inducing vulnerability to InhA inhibition restores isoniazid susceptibility in drug resistant Mycoba ... | Harrison, Gregory A; Cho, Kevin; Wang, Erin R; Sarkar, Souvik; Almqvist, Fredrik; Patti, Gary ... | R35ES028365 | bioRxiv (2023 Feb 07) |
36798348
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2023 |
| Mitochondrial Pyruvate Carrier Inhibition Attenuates Hepatic Stellate Cell Activation and Liver Inju ... | Habibi, Mohammad; Ferguson, Daniel; Eichler, Sophie J; Chan, Mandy M; LaPoint, Andrew; Shew, T ... | R35ES028365 | bioRxiv (2023 Aug 25) |
36824926
|
2023 |
| MPI-VGAE: protein-metabolite enzymatic reaction link learning by variational graph autoencoders. | Wang, Cheng; Yuan, Chuang; Wang, Yahui; Chen, Ranran; Shi, Yuying; Zhang, Tao; Xue, Fuzhong; ... | R35ES028365 | Brief Bioinform (2023 Jul 20) |
37225420
|
2023 |
| Stromal DDR2 Promotes Ovarian Cancer Metastasis through Regulation of Metabolism and Secretion of Ex ... | Schab, Angela M; Greenwade, Molly M; Stock, Elizabeth; Lomonosova, Elena; Cho, Kevin; Grither, ... | R35ES028365 | Mol Cancer Res (2023 Nov 01) |
37527178
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2023 |
| The Warburg effect: a signature of mitochondrial overload. | Wang, Yahui; Patti, Gary J | R35ES028365 | Trends Cell Biol (2023 Dec) |
37117116
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2023 |
| A multidimensional metabolomics workflow to image biodistribution and evaluate pharmacodynamics in a ... | Jackstadt, Madelyn M; Chamberlain, Casey A; Doonan, Steven R; Shriver, Leah P; Patti, Gary J | R35ES028365 | Dis Model Mech (2022 Aug 01) |
35972155
|
2022 |
| An Untargeted Metabolomics Workflow that Scales to Thousands of Samples for Population-Based Studies ... | Stancliffe, Ethan; Schwaiger-Haber, Michaela; Sindelar, Miriam; Murphy, Matthew J; Soerensen, M ... | R35ES028365 | Anal Chem (2022 Dec 20) |
36475608
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2022 |
| Combining Isotopologue Workflows and Simultaneous Multidimensional Separations to Detect, Identify, ... | Dodds, James N; Wang, Lingjue; Patti, Gary J; Baker, Erin S | P30ES025128, P42ES027704, P42ES031009, R35ES028365 | Anal Chem (2022 Feb 08) |
35089687
|
2022 |
| GAS6-AXL Inhibition by AVB-500 Overcomes Resistance to Paclitaxel in Endometrial Cancer by Decreasin ... | Bruce, Shaina F; Cho, Kevin; Noia, Hollie; Lomonosova, Elena; Stock, Elizabeth C; Oplt, Alyssa ... | R35ES028365 | Mol Cancer Ther (2022 Aug 02) |
35588308
|
2022 |
| Mitochondrial pyruvate carrier inhibitors improve metabolic parameters in diet-induced obese mice. | Hodges, Wesley T; Jarasvaraparn, Chaowapong; Ferguson, Daniel; Griffett, Kristine; Gill, Lauren ... | R35ES028365 | J Biol Chem (2022 Feb) |
34973337
|
2022 |
| Monounsaturated and Diunsaturated Fatty Acids Sensitize Cervical Cancer to Radiation Therapy. | Muhammad, Naoshad; Ruiz, Fiona; Stanley, Jennifer; Rashmi, Ramachandran; Cho, Kevin; Jayachandr ... | R35ES028365 | Cancer Res (2022 Dec 16) |
36214635
|
2022 |
| Quick tips for re-using metabolomics data. | Stancliffe, Ethan; Patti, Gary J | R35ES028365 | Nat Cell Biol (2022 Nov) |
36280705
|
2022 |
| Saturation of the mitochondrial NADH shuttles drives aerobic glycolysis in proliferating cells. | Wang, Yahui; Stancliffe, Ethan; Fowle-Grider, Ronald; Wang, Rencheng; Wang, Cheng; Schwaiger-Ha ... | R35ES028365 | Mol Cell (2022 Sep 01) |
35973426
|
2022 |
| Sex differences in brain tumor glutamine metabolism reveal sex-specific vulnerabilities to treatment ... | Sponagel, Jasmin; Jones, Jill K; Frankfater, Cheryl; Zhang, Shanshan; Tung, Olivia; Cho, Kevin ... | R35ES028365 | Med (2022 Nov 11) |
36108629
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2022 |
| Silencing alanine transaminase 2 in diabetic liver attenuates hyperglycemia by reducing gluconeogene ... | Martino, Michael R; Gutiérrez-Aguilar, Manuel; Yiew, Nicole K H; Lutkewitte, Andrew J; Singer, ... | R35ES028365 | Cell Rep (2022 Apr 26) |
35476997
|
2022 |
| Targeting fatty acid β-oxidation impairs monocyte differentiation and prolongs heart allograft survi ... | Zhu, Yuehui; Dun, Hao; Ye, Li; Terada, Yuriko; Shriver, Leah P; Patti, Gary J; Kreisel, Danie ... | R35ES028365 | JCI Insight (2022 Apr 08) |
35239515
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2022 |
| A Protocol for Untargeted Metabolomic Analysis: From Sample Preparation to Data Processing. | Souza, Amanda L; Patti, Gary J | R35ES028365 | Methods Mol Biol (2021) |
34060055
|
2021 |
| DecoID improves identification rates in metabolomics through database-assisted MS/MS deconvolution. | Stancliffe, Ethan; Schwaiger-Haber, Michaela; Sindelar, Miriam; Patti, Gary J | R35ES028365 | Nat Methods (2021 Jul) |
34239103
|
2021 |
| Deletion of Glut1 in early postnatal cartilage reprograms chondrocytes toward enhanced glutamine oxi ... | Wang, Cuicui; Ying, Jun; Niu, Xiangfeng; Li, Xiaofei; Patti, Gary J; Shen, Jie; O'Keefe, Regi ... | R35ES028365 | Bone Res (2021 Aug 23) |
34426569
|
2021 |
| HERMES: a molecular-formula-oriented method to target the metabolome. | Giné, Roger; Capellades, Jordi; Badia, Josep M; Vughs, Dennis; Schwaiger-Haber, Michaela; Alexa ... | R35ES028365 | Nat Methods (2021 Nov) |
34725482
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2021 |
| HIF1α is required for NK cell metabolic adaptation during virus infection. | Victorino, Francisco; Bigley, Tarin M; Park, Eugene; Yao, Cong-Hui; Benoit, Jeanne; Yang, Li-P ... | R35ES028365 | Elife (2021 Aug 16) |
34396954
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2021 |
| Isotope tracing in adult zebrafish reveals alanine cycling between melanoma and liver. | Naser, Fuad J; Jackstadt, Madelyn M; Fowle-Grider, Ronald; Spalding, Jonathan L; Cho, Kevin; St ... | R35ES028365 | Cell Metab (2021 07 06) |
33989520
|
2021 |
| Longitudinal Metabolomics of Human Plasma Reveals Robust Prognostic Markers of COVID-19 Disease Seve ... | Sindelar, Miriam; Stancliffe, Ethan; Schwaiger-Haber, Michaela; Anbukumar, Dhanalakshmi S; Albre ... | R35ES028365 | medRxiv (2021 Feb 08) |
33564793
|
2021 |
| Loss of SNORA73 reprograms cellular metabolism and protects against steatohepatitis. | Sletten, Arthur C; Davidson, Jessica W; Yagabasan, Busra; Moores, Samantha; Schwaiger-Haber, Mi ... | R35ES028365 | Nat Commun (2021 Sep 01) |
34471131
|
2021 |
| Quantitative rotational-echo double resonance for Carbon-13 spin clusters. | Matsuoka, Shigeru; Sindelar, Miriam; Bansal, Sonal; Patti, Gary J; Schaefer, Jacob | R35ES028365 | J Magn Reson (2021 09) |
34364107
|
2021 |
| Targeting unique biological signals on the fly to improve MS/MS coverage and identification efficien ... | Cho, Kevin; Schwaiger-Haber, Michaela; Naser, Fuad J; Stancliffe, Ethan; Sindelar, Miriam; Patt ... | R35ES028365 | Anal Chim Acta (2021 Mar 08) |
33551064
|
2021 |
| Alteration of Cellular Reduction Potential Will Change 64Cu-ATSM Signal With or Without Hypoxia. | Floberg, John M; Wang, Lingjue; Bandara, Nilantha; Rashmi, Ramachandran; Mpoy, Cedric; Garbow, ... | R35ES028365 | J Nucl Med (2020 03) |
31586008
|
2020 |
| Chemical Discovery in the Era of Metabolomics. | Sindelar, Miriam; Patti, Gary J | R35ES028365 | J Am Chem Soc (2020 05 20) |
32275430
|
2020 |
| Dietary serine-microbiota interaction enhances chemotherapeutic toxicity without altering drug conve ... | Ke, Wenfan; Saba, James A; Yao, Cong-Hui; Hilzendeger, Michael A; Drangowska-Way, Anna; Joshi, ... | R35ES028365 | Nat Commun (2020 May 22) |
32444616
|
2020 |
| Dose-Response Metabolomics To Understand Biochemical Mechanisms and Off-Target Drug Effects with the ... | Yao, Cong-Hui; Wang, Lingjue; Stancliffe, Ethan; Sindelar, Miriam; Cho, Kevin; Yin, Weitong; W ... | R35ES028365 | Anal Chem (2020 01 21) |
31804057
|
2020 |
| Glutaminase Inhibitors Induce Thiol-Mediated Oxidative Stress and Radiosensitization in Treatment-Re ... | Rashmi, Ramachandran; Jayachandran, Kay; Zhang, Jin; Menon, Vishnu; Muhammad, Naoshad; Zahner, ... | P30ES005605, R35ES028365 | Mol Cancer Ther (2020 12) |
33087507
|
2020 |
| Leveraging insights into cancer metabolism-a symposium report. | Cable, Jennifer; Finley, Lydia; Tu, Benjamin P; Patti, Gary J; Oliver, Trudy G; Vardhana, Sant ... | R35ES028365 | Ann N Y Acad Sci (2020 02) |
31792987
|
2020 |
| A Protocol to Compare Methods for Untargeted Metabolomics. | Wang, Lingjue; Naser, Fuad J; Spalding, Jonathan L; Patti, Gary J | R35ES028365 | Methods Mol Biol (2019) |
30315456
|
2019 |
| Exogenous Monounsaturated Fatty Acids Promote a Ferroptosis-Resistant Cell State. | Magtanong, Leslie; Ko, Pin-Joe; To, Milton; Cao, Jennifer Yinuo; Forcina, Giovanni C; Tarangelo ... | R35ES028365 | Cell Chem Biol (2019 Mar 21) |
30686757
|
2019 |
| Hepatic monoacylglycerol acyltransferase 1 is induced by prolonged food deprivation to modulate the ... | Lutkewitte, Andrew J; McCommis, Kyle S; Schweitzer, George G; Chambers, Kari T; Graham, Mark J; ... | R35ES028365 | J Lipid Res (2019 03) |
30610082
|
2019 |
| Hepatocyte-Macrophage Acetoacetate Shuttle Protects against Tissue Fibrosis. | Puchalska, Patrycja; Martin, Shannon E; Huang, Xiaojing; Lengfeld, Justin E; Daniel, Bence; Gra ... | R35ES028365 | Cell Metab (2019 02 05) |
30449686
|
2019 |
| Impaired skeletal muscle mitochondrial pyruvate uptake rewires glucose metabolism to drive whole-bod ... | Sharma, Arpit; Oonthonpan, Lalita; Sheldon, Ryan D; Rauckhorst, Adam J; Zhu, Zhiyong; Tompkins, ... | R35ES028365 | Elife (2019 Jul 18) |
31305240
|
2019 |
| International Ring Trial of a High Resolution Targeted Metabolomics and Lipidomics Platform for Seru ... | Thompson, J Will; Adams, Kendra J; Adamski, Jerzy; Asad, Yasmin; Borts, David; Bowden, John A; ... | R35ES028365 | Anal Chem (2019 11 19) |
31638379
|
2019 |
| Mitochondrial fusion supports increased oxidative phosphorylation during cell proliferation. | Yao, Cong-Hui; Wang, Rencheng; Wang, Yahui; Kung, Che-Pei; Weber, Jason D; Patti, Gary J | R35ES028365 | Elife (2019 01 29) |
30694178
|
2019 |
| Ontology-based metabolomics data integration with quality control. | Buendia, Patricia; Bradley, Ray M; Taylor, Thomas J; Schymanski, Emma L; Patti, Gary J; Kabuka, ... | R35ES028365 | Bioanalysis (2019 Jun) |
31179719
|
2019 |
| Perspectives on Data Analysis in Metabolomics: Points of Agreement and Disagreement from the 2018 AS ... | Baker, Erin S; Patti, Gary J | R35ES028365 | J Am Soc Mass Spectrom (2019 Oct) |
31440979
|
2019 |
| Systems-level analysis of isotopic labeling in untargeted metabolomic data by X13CMS. | Llufrio, Elizabeth M; Cho, Kevin; Patti, Gary J | R35ES028365 | Nat Protoc (2019 07) |
31168088
|
2019 |
| Consumption of NADPH for 2-HG Synthesis Increases Pentose Phosphate Pathway Flux and Sensitizes Cell ... | Gelman, Susan J; Naser, Fuad; Mahieu, Nathaniel G; McKenzie, Lisa D; Dunn, Gavin P; Chheda, Mi ... | R35ES028365 | Cell Rep (2018 01 09) |
29320744
|
2018 |
| Identifying off-target effects of etomoxir reveals that carnitine palmitoyltransferase I is essentia ... | Yao, Cong-Hui; Liu, Gao-Yuan; Wang, Rencheng; Moon, Sung Ho; Gross, Richard W; Patti, Gary J | R35ES028365 | PLoS Biol (2018 Mar) |
29596410
|
2018 |
| Isotope Tracing Untargeted Metabolomics Reveals Macrophage Polarization-State-Specific Metabolic Coo ... | Puchalska, Patrycja; Huang, Xiaojing; Martin, Shannon E; Han, Xianlin; Patti, Gary J; Crawford, ... | R35ES028365 | iScience (2018 Nov 30) |
30448730
|
2018 |
| Mechanism of High-Level Daptomycin Resistance in Corynebacterium striatum. | Goldner, Nicholas K; Bulow, Christopher; Cho, Kevin; Wallace, Meghan; Hsu, Fong-Fu; Patti, Gar ... | R35ES028365 | mSphere (2018 08 08) |
30089649
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2018 |
| Metabolic and Transcriptional Modules Independently Diversify Plasma Cell Lifespan and Function. | Lam, Wing Y; Jash, Arijita; Yao, Cong-Hui; D'Souza, Lucas; Wong, Rachel; Nunley, Ryan M; Meare ... | R35ES028365 | Cell Rep (2018 Aug 28) |
30157439
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2018 |
| Sorting cells alters their redox state and cellular metabolome. | Llufrio, Elizabeth M; Wang, Lingjue; Naser, Fuad J; Patti, Gary J | R35ES028365 | Redox Biol (2018 Jun) |
29627745
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2018 |
| Trace Phosphate Improves ZIC-pHILIC Peak Shape, Sensitivity, and Coverage for Untargeted Metabolomic ... | Spalding, Jonathan L; Naser, Fuad J; Mahieu, Nathaniel G; Johnson, Stephen L; Patti, Gary J | R35ES028365 | J Proteome Res (2018 10 05) |
30160483
|
2018 |
| Transport-exclusion pharmacology to localize lactate dehydrogenase activity within cells. | Niu, Xiangfeng; Chen, Ying-Jr; Crawford, Peter A; Patti, Gary J | R35ES028365 | Cancer Metab (2018) |
30559963
|
2018 |
| Two complementary reversed-phase separations for comprehensive coverage of the semipolar and nonpola ... | Naser, Fuad J; Mahieu, Nathaniel G; Wang, Lingjue; Spalding, Jonathan L; Johnson, Stephen L; Pa ... | R35ES028365 | Anal Bioanal Chem (2018 Feb) |
29256075
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2018 |
| Maximizing the value of metabolomic data. | Goeddel, L C; Patti, G J | R35ES028365 | Bioanalysis (2012 Sep) |
23046261
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2012 |