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National Institute of Environmental Health Sciences

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Publication Detail

Title: Studies of mutagenesis and neoplastic transformation by bivalent metal ions and ionizing radiation.

Authors: Little, J B; Frenial, J M; Coppey, J

Published In Teratog Carcinog Mutagen, (1988)

Abstract: We examined the influence of nontoxic concentrations of each of two essential (Zn++ and Mn++) and one nonessential (Ni++) bivalent metal ions on spontaneous and radiation-induced neoplastic transformation and specific gene mutations in mammalian cells. All three metals induced low levels of transformation in mouse BALB/3T3 cells but exerted no mutagenic effect in CHO cells (hprt locus) over a broad range of concentrations. Continuous incubation for 8 or 15 days with each of the metal ions did not enhance the frequency of cell killing, transformation, or mutations induced by acute exposure to x-rays. Zn++, however, had a small but consistent protective effect on the induction of all three endpoints by x-irradiation.

PubMed ID: 2905837 Exiting the NIEHS site

MeSH Terms: No MeSH terms associated with this publication

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