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Publication Detail

Title: Biosynthetic origin of aflatoxin G1: confirmation of sterigmatocystin and lack of confirmation of aflatoxin B1 as precursors.

Authors: Henderberg, A; Bennett, J W; Lee, L S

Published In J Gen Microbiol, (1988 Mar)

Abstract: The origin of aflatoxin G1 was studied using mutant strains of Aspergillus parasiticus blocked early in the pathway and by tracing 14C-labelled aflatoxin B1 (AFB1) in wild-type A. flavus and A. parasiticus strains. Sterigmatocystin (ST) was a precursor of AFB1, AFG1 and AFG2 in the four mutants examined. The identity of AFG1 was confirmed by mass spectrometry. No evidence for conversion of AFB1 to AFG1 was found. A rigorously controlled study of conversions of radioactivity based on preparative thin-layer chromatography of aflatoxins demonstrated that low levels of aflatoxin interconversions previously reported in the literature might actually be artifacts.

PubMed ID: 3141572 Exiting the NIEHS site

MeSH Terms: Aflatoxin B1; Aflatoxins/biosynthesis*; Aflatoxins/metabolism*; Aspergillus/metabolism; Biotransformation; Chromatography, Thin Layer; Sterigmatocystin/pharmacokinetics*; Xanthenes/pharmacokinetics*

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