Skip Navigation
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

National Institute of Environmental Health Sciences

Use this QR code to view the newest version of this document
Use this QR code to view the newest version of this document

Your Environment. Your Health.

Publication Detail

Title: Transforming growth factor-beta 1 inhibits nucleosomal fragmentation in human keratinocytes following loss of adhesion.

Authors: Sachsenmeier, K F; Sheibani, N; Schlosser, S J; Allen-Hoffmann, B L

Published In J Biol Chem, (1996 Jan 05)

Abstract: We have investigated the role of transforming growth factor-beta 1 (TGF-beta 1) in suspension-induced programmed cell death of cultured human keratinocytes. Suspension of keratinocytes in semisolid medium induces TGF-beta 1 mRNA levels and synthesis of bioactive TGF-beta 1 protein. Concomitant with the suspension-induced increase in secreted TGF-beta 1 levels, steady state mRNA levels for c-myc are decreased. Both exogenously added and endogenously produced TGF-beta 1 attenuate suspension-induced nucleosomal fragmentation in keratinocytes. We propose that TGF-beta 1 may function to protect keratinocytes from DNA fragmentation following loss of cell-substratum and/or cell-cell contact. Taken together, our findings suggest that loss of cell-substratum and/or cell-cell adhesion is an important component of an apoptotic signal transduction cascade regulated by TGF-beta 1 in normal human stratified squamous epithelia.

PubMed ID: 8550610 Exiting the NIEHS site

MeSH Terms: No MeSH terms associated with this publication

Back
to Top