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National Institute of Environmental Health Sciences

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Publication Detail

Title: Characteristics of radiation-induced neoplastic transformation in vitro.

Authors: Little, J B

Published In Leuk Res, (1986)

Abstract: Data are presented to support the hypothesis that the initial step in the morphologic transformation of irradiated rodent cells is a frequent cellular event involving a large fraction of the irradiated population. This process appears to involve DNA damage, but not to represent a targeted mutation in specific structural gene(s). Morphologic transformation and immortalization appear to be distinct steps in the overall process of transformation. In contradistinction to rodent cells, immortalization is a very rare event in human diploid cells which is induced at extremely low frequencies. The hypothesis is presented that immortality develops among clones of cells bearing stable chromosomal rearrangements which emerge during the proliferation of a population of radiation damaged cells.

PubMed ID: 3736107 Exiting the NIEHS site

MeSH Terms: No MeSH terms associated with this publication

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