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Publication Detail

Title: The therapeutic use of 2,3-dimercaptopropane-1-sulfonate in two cases of inorganic mercury poisoning.

Authors: Campbell, J R; Clarkson, T W; Omar, M D

Published In JAMA, (1986 Dec 12)

Abstract: Two patients had heavy metal intoxication resulting from industrial exposure to mercury vapors. One patient remained asymptomatic despite high urinary mercury levels. The second presented with a documented toxic reaction, including abnormal electromyograms and hematuria. Treatment was begun with 2,3-dimercaptopropane-1-sulfonate, and investigational drug used under Food and Drug Administration guidelines (IND 19,276). Use in both patients resulted in a dramatic change in excretion half-life of the mercury, from 33.1 days before treatment to 11.2 days during therapy. No significant toxic effects related to drug therapy were observed. Clearing of hematuria and reversal of electromyographic abnormalities were prompt in the symptomatic patient. Therapy with 2,3-dimercaptopropane-1-sulfonate was effective in these two patients.

PubMed ID: 3783847 Exiting the NIEHS site

MeSH Terms: No MeSH terms associated with this publication

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