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National Institute of Environmental Health Sciences

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Your Environment. Your Health.

Publication Detail

Title: Chromosome 14 marker appearance in a human B lymphoblastoid cell line of nonmalignant origin.

Authors: Yandell, D W; Little, J B

Published In Cancer Genet Cytogenet, (1986 Feb 15)

Abstract: A human B cell lymphoblastoid cell line of nonmalignant origin, derived 16 years ago, now carries a 14q+ marker chromosome in 100% of the cells analyzed. This marker was not apparent in karyotypes prepared 1 year after establishment of the line and, thus, presumably arose in culture. The cell line now grows more rapidly than typical B cell cultures and has an unusually high cloning efficiency (60%-90%). Using Southern blot hybridization, we have analyzed the arrangement of 13 onc genes that are often associated with human malignancy, including c-myc. None of these onc genes appear to be rearranged in this cell line.

PubMed ID: 3080224 Exiting the NIEHS site

MeSH Terms: No MeSH terms associated with this publication

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