Skip Navigation
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

National Institute of Environmental Health Sciences

Use this QR code to view the newest version of this document
Use this QR code to view the newest version of this document

Your Environment. Your Health.

Publication Detail

Title: Association of 59iron oxide with alveolar macrophages during alveolar clearance.

Authors: Lehnert, B E; Morrow, P E

Published In Exp Lung Res, (1985)

Abstract: Long-Evans hooded rats were exposed for 2 h to aerosols of hydrated, radiolabeled iron (59Fe) oxide (MMAD = 1.6 micron; sigma g = 3.0) in order to produce a low mass burden of particles (approximately equal to 30 micrograms) in the lung. The kinetics of particle clearance and the association of the particles with alveolar macrophages (AM) were measured. Two to four hours after exposure, lavaged particles were linearly related to AM numbers harvested, and 60% of the 59Fe activity was physically associated with AM. By 24 h, greater than 90% of the lavaged particles were associated with AM. Such an association was found for at least 75% of the particulate burdens in the lungs. If all the 59Fe is assumed to be AM associated, the 59Fe per AM predicts the total AM population size to be 2.14 X 10(7) cells. This number, in conjunction with the alveolar clearance rate of the particles, suggested the number of AM leaving the lung daily was 2.8 X 10(5) cells.

PubMed ID: 4065055 Exiting the NIEHS site

MeSH Terms: No MeSH terms associated with this publication

Back
to Top