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Publication Detail

Title: Changes in frequencies of chromosomal aberrations and sister chromatid exchanges during confluent holding recovery in X-irradiated normal human diploid fibroblasts.

Authors: Nagasawa, H; Little, J B

Published In Int J Radiat Biol Relat Stud Phys Chem Med, (1985 Oct)

Abstract: The time course of the changes in survival and cytogenetic damage was studied in X-irradiated cultures of human diploid fibroblasts before release from density-inhibition of growth. The frequency of chromosomal aberrations declined rapidly during the initial 2 h recovery interval in parallel with an enhancement in survival. The frequency of sister chromatid exchanges (SCE) increased during this interval reaching a maximum of 2 h, then declined. These changes are discussed in relation to previous observations on X-ray induced cytogenetic damage and malignant transformation in rodent cells under similar conditions.

PubMed ID: 3876310 Exiting the NIEHS site

MeSH Terms: No MeSH terms associated with this publication

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